Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis

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dc.contributor.advisorSegal, Heidien_ZA
dc.contributor.authorEvans, Joannaen_ZA
dc.date.accessioned2014-12-28T20:05:42Z
dc.date.available2014-12-28T20:05:42Z
dc.date.issued2010en_ZA
dc.description.abstractThe emergence of antibiotic resistant strains of Mycobacterium tuberculosis, coupled with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. tuberculosis have been developed, but the sensitivity with which these assays identify resistance differs geographically. Additionally, the identification of phenotypically resistant isolates with no identifiable genotypic marker suggests that other factors, such as differential gene expression, may play a role in the development of drug resistance in M. tuberculosis. This investigation aims to both develop and evaluate rapid genotypic assays for the detection of resistance to both first- and second-line drugs in M. tuberculosis, and to investigate the role of alternative sigma factors in the progression to multidrug resistant M. tuberculosis.en_ZA
dc.identifier.apacitationEvans, J. (2010). <i>Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology. Retrieved from http://hdl.handle.net/11427/10434en_ZA
dc.identifier.chicagocitationEvans, Joanna. <i>"Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2010. http://hdl.handle.net/11427/10434en_ZA
dc.identifier.citationEvans, J. 2010. Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Evans, Joanna AB - The emergence of antibiotic resistant strains of Mycobacterium tuberculosis, coupled with the time it takes to perform phenotypic drug susceptibility testing of this organism, makes the treatment of tuberculosis increasingly difficult. Several genotypic assays for the rapid detection of drug resistance in M. tuberculosis have been developed, but the sensitivity with which these assays identify resistance differs geographically. Additionally, the identification of phenotypically resistant isolates with no identifiable genotypic marker suggests that other factors, such as differential gene expression, may play a role in the development of drug resistance in M. tuberculosis. This investigation aims to both develop and evaluate rapid genotypic assays for the detection of resistance to both first- and second-line drugs in M. tuberculosis, and to investigate the role of alternative sigma factors in the progression to multidrug resistant M. tuberculosis. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis TI - Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis UR - http://hdl.handle.net/11427/10434 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10434
dc.identifier.vancouvercitationEvans J. Investigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10434en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Microbiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Microbiologyen_ZA
dc.titleInvestigation of the genetic basis of antibiotic resistance in Mycobacterium tuberculosisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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