The structural neurobiology of social anxiety disorder : a clinical neuroimaging study

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dc.contributor.advisorStein, Dan Jen_ZA
dc.contributor.advisorLochner, Christineen_ZA
dc.contributor.advisorBrooks, Samantha Jen_ZA
dc.contributor.authorHattingh, Coenraad Jacobusen_ZA
dc.date.accessioned2015-12-03T14:12:10Z
dc.date.available2015-12-03T14:12:10Z
dc.date.issued2015en_ZA
dc.descriptionIncludes bibliographical referencesen_ZA
dc.description.abstractWhile a number of studies have explored the functional neuroanatomy of social anxiety disorder (SAD), comparatively few studies have investigated the structural underpinnings in SAD. 18 psychopharmacologically and psychotherapeutically naïve adult patients with a primary Axis I diagnosis of generalized social anxiety disorder and 18 demographically (age, gender and education) matched healthy controls underwent 3T structural magnetic resonance imaging. A manual tracing protocol was specifically developed to compute the volume of the most prominent subcortical gray matter structures implicated in SAD by previous functional research. Cortical thickness was estimated using an automated algorithm and whole brain analyses of white matter structure were performed using FSL's tract - based spatial statistics comparing fractional anisotropy (FA), mean diffusivity (MD) in individuals with SAD. Manual tracing demonstrated that compared to controls, SAD patients showed an enlarged right globus pallidus. Cortical thickness analyses demonstrated significant cortical thinning in the left isthmus of the cingulate gyrus, the left temporal pole, and the left superior temporal gyrus. Analyses of white matter tractographic data demonstrated reduced FA in in the genu, splenium and tapetum of the corpus callosum. Additionally reduced FA was noticed in the fornix and the right cingulum. Reduced FA was also noted in bilateral corticospinal tracts and the right corona radiata. The results demonstrate structural alterations in limbic circuitry as well as involvement of the basal glanglia and their cortical projections and input pathways.en_ZA
dc.identifier.apacitationHattingh, C. J. (2015). <i>The structural neurobiology of social anxiety disorder : a clinical neuroimaging study</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health. Retrieved from http://hdl.handle.net/11427/15544en_ZA
dc.identifier.chicagocitationHattingh, Coenraad Jacobus. <i>"The structural neurobiology of social anxiety disorder : a clinical neuroimaging study."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health, 2015. http://hdl.handle.net/11427/15544en_ZA
dc.identifier.citationHattingh, C. 2015. The structural neurobiology of social anxiety disorder : a clinical neuroimaging study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Hattingh, Coenraad Jacobus AB - While a number of studies have explored the functional neuroanatomy of social anxiety disorder (SAD), comparatively few studies have investigated the structural underpinnings in SAD. 18 psychopharmacologically and psychotherapeutically naïve adult patients with a primary Axis I diagnosis of generalized social anxiety disorder and 18 demographically (age, gender and education) matched healthy controls underwent 3T structural magnetic resonance imaging. A manual tracing protocol was specifically developed to compute the volume of the most prominent subcortical gray matter structures implicated in SAD by previous functional research. Cortical thickness was estimated using an automated algorithm and whole brain analyses of white matter structure were performed using FSL's tract - based spatial statistics comparing fractional anisotropy (FA), mean diffusivity (MD) in individuals with SAD. Manual tracing demonstrated that compared to controls, SAD patients showed an enlarged right globus pallidus. Cortical thickness analyses demonstrated significant cortical thinning in the left isthmus of the cingulate gyrus, the left temporal pole, and the left superior temporal gyrus. Analyses of white matter tractographic data demonstrated reduced FA in in the genu, splenium and tapetum of the corpus callosum. Additionally reduced FA was noticed in the fornix and the right cingulum. Reduced FA was also noted in bilateral corticospinal tracts and the right corona radiata. The results demonstrate structural alterations in limbic circuitry as well as involvement of the basal glanglia and their cortical projections and input pathways. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - The structural neurobiology of social anxiety disorder : a clinical neuroimaging study TI - The structural neurobiology of social anxiety disorder : a clinical neuroimaging study UR - http://hdl.handle.net/11427/15544 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15544
dc.identifier.vancouvercitationHattingh CJ. The structural neurobiology of social anxiety disorder : a clinical neuroimaging study. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/15544en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Psychiatry and Mental Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherNeuroscienceen_ZA
dc.titleThe structural neurobiology of social anxiety disorder : a clinical neuroimaging studyen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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