Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design

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dc.contributor.advisorDorfman, Jeffreyen_ZA
dc.contributor.authorJacob, Rajesh Abrahamen_ZA
dc.date.accessioned2014-10-21T13:47:48Z
dc.date.available2014-10-21T13:47:48Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractInducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine. The Membrane Proximal External Region (MPER) within the HIV- 1 gp41 envelope is a promising vaccine target. The MPER is highly conserved, functionally constrained, facilitates virus fusion and is targeted by broadly neutralizing monoclonal antibodies. The objectives of this research were 1) To evaluate the neutralization breadth of antibodies induced by epitopes within the MPER compared to the PG9/16-site in chronically HIV-1-infected individuals, 2) to identify neutralization resistant HIV-1 isolates (using plasma samples infected with the same subtype) and to characterize their sensitivity to anti-MPER antibodies and 3) to determine the accessibility of the MPER to HIV-1 induced polyclonal anti-MPER antibodies in a highly neutralization resistant virus (253-11; CRF02_AG subtype).en_ZA
dc.identifier.apacitationJacob, R. A. (2014). <i>Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/8707en_ZA
dc.identifier.chicagocitationJacob, Rajesh Abraham. <i>"Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2014. http://hdl.handle.net/11427/8707en_ZA
dc.identifier.citationJacob, R. 2014. Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Jacob, Rajesh Abraham AB - Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine. The Membrane Proximal External Region (MPER) within the HIV- 1 gp41 envelope is a promising vaccine target. The MPER is highly conserved, functionally constrained, facilitates virus fusion and is targeted by broadly neutralizing monoclonal antibodies. The objectives of this research were 1) To evaluate the neutralization breadth of antibodies induced by epitopes within the MPER compared to the PG9/16-site in chronically HIV-1-infected individuals, 2) to identify neutralization resistant HIV-1 isolates (using plasma samples infected with the same subtype) and to characterize their sensitivity to anti-MPER antibodies and 3) to determine the accessibility of the MPER to HIV-1 induced polyclonal anti-MPER antibodies in a highly neutralization resistant virus (253-11; CRF02_AG subtype). DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design TI - Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design UR - http://hdl.handle.net/11427/8707 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/8707
dc.identifier.vancouvercitationJacob RA. Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/8707en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleEvaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine designen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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