Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder

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dc.contributor.advisorRussell, Vivienne Aen_ZA
dc.contributor.advisorKellaway, Lauristonen_ZA
dc.contributor.advisorStein, Dan Jen_ZA
dc.contributor.authorWomersley, Jacqueline Samanthaen_ZA
dc.date.accessioned2014-11-11T06:56:13Z
dc.date.available2014-11-11T06:56:13Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterised by age-inappropriate levels of inattention, hyperactivity and impulsivity and is theorised to be caused by dopaminergic dysregulation. Developmental stress interrupts vulnerable periods of neural developmental and has also been found to induce disturbances in dopamine. ADHD and developmental stress are both associated with a higher risk of abusing psychostimulants; drugs that act on the dopaminergic system to elicit a sense of reward. Central to dopamine regulation is the dopamine transporter (DAT), which is responsible for the rapid reuptake of released dopamine and therefore the regulation of extracellul ar dopamine concentration. The aim of this study was to examine the effects of developmental stress and psychostimulant exposure on dopaminergic function, more specifically DAT, in a rat model of ADHD, the spontaneously hypertensive rat (SHR) versus Wistar Kyoto (WKY) and Sprague-Dawley (SD) control strains.en_ZA
dc.identifier.apacitationWomersley, J. S. (2014). <i>Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/9530en_ZA
dc.identifier.chicagocitationWomersley, Jacqueline Samantha. <i>"Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2014. http://hdl.handle.net/11427/9530en_ZA
dc.identifier.citationWomersley, J. 2014. Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Womersley, Jacqueline Samantha AB - Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterised by age-inappropriate levels of inattention, hyperactivity and impulsivity and is theorised to be caused by dopaminergic dysregulation. Developmental stress interrupts vulnerable periods of neural developmental and has also been found to induce disturbances in dopamine. ADHD and developmental stress are both associated with a higher risk of abusing psychostimulants; drugs that act on the dopaminergic system to elicit a sense of reward. Central to dopamine regulation is the dopamine transporter (DAT), which is responsible for the rapid reuptake of released dopamine and therefore the regulation of extracellul ar dopamine concentration. The aim of this study was to examine the effects of developmental stress and psychostimulant exposure on dopaminergic function, more specifically DAT, in a rat model of ADHD, the spontaneously hypertensive rat (SHR) versus Wistar Kyoto (WKY) and Sprague-Dawley (SD) control strains. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder TI - Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder UR - http://hdl.handle.net/11427/9530 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9530
dc.identifier.vancouvercitationWomersley JS. Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9530en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleMethamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorderen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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