The role of the CCR5 co-receptor conformation in HIV fusion
Master Thesis
2008
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University of Cape Town
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Abstract
This thesis aimed to better define the co-receptor conformation by determining whether mutants of the CCR5 receptor stabilized in the active conformation were less able to mediate HIV fussion. Eight mutant receptors were generated by site-directed mutagenesis and screened for constitutive activity using intracellutal signaling assays.
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Includes bibliographical references (leaves 71-80).
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Reference:
Salo, A. 2008. The role of the CCR5 co-receptor conformation in HIV fusion. University of Cape Town.