Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting

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dc.contributor.advisorSwingler, George Hen_ZA
dc.contributor.advisorMyer, Landonen_ZA
dc.contributor.advisorRobertson, Nicolaen_ZA
dc.contributor.authorHorn, Alan Richarden_ZA
dc.date.accessioned2015-01-03T18:20:50Z
dc.date.available2015-01-03T18:20:50Z
dc.date.issued2013en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractHypoxic ischaemic encephalopathy (HIE) after birth is an important cause of neonatal morbidity and mortality, particularly in resource-limited regions. Therapeutic hypothermia initiated within the first 6 hours of life, in settings that can offer neonatal intensive care, is a therapy that can reduce death or severe disability in newborn infants with moderate or severe HIE. Therapeutic hypothermia has not been shown to be safe or effective in low-resource settings where neonatal intensive care is not available; however, there are situations such as in some centres in South Africa, where limited neonatal intensive care (NICU) is available against a background of moderate neonatal mortality rates, relatively low socio-economic conditions and limited capacity for long-term follow-up. In such settings, accurate case definition and early prediction of HIE and outcome may assist with the appropriate allocation of resources. The amplitude-integrated electro-encephalogram (aEEG) is an ideal tool to use for prediction of outcome and the need for cooling, but it’s availability is limited, particularly at primary and secondary hospitals.en_ZA
dc.identifier.apacitationHorn, A. R. (2013). <i>Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/11188en_ZA
dc.identifier.chicagocitationHorn, Alan Richard. <i>"Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2013. http://hdl.handle.net/11427/11188en_ZA
dc.identifier.citationHorn, A. 2013. Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Horn, Alan Richard AB - Hypoxic ischaemic encephalopathy (HIE) after birth is an important cause of neonatal morbidity and mortality, particularly in resource-limited regions. Therapeutic hypothermia initiated within the first 6 hours of life, in settings that can offer neonatal intensive care, is a therapy that can reduce death or severe disability in newborn infants with moderate or severe HIE. Therapeutic hypothermia has not been shown to be safe or effective in low-resource settings where neonatal intensive care is not available; however, there are situations such as in some centres in South Africa, where limited neonatal intensive care (NICU) is available against a background of moderate neonatal mortality rates, relatively low socio-economic conditions and limited capacity for long-term follow-up. In such settings, accurate case definition and early prediction of HIE and outcome may assist with the appropriate allocation of resources. The amplitude-integrated electro-encephalogram (aEEG) is an ideal tool to use for prediction of outcome and the need for cooling, but it’s availability is limited, particularly at primary and secondary hospitals. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting TI - Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting UR - http://hdl.handle.net/11427/11188 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11188
dc.identifier.vancouvercitationHorn AR. Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11188en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPaediatricsen_ZA
dc.titleEarly prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited settingen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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