Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa
Master Thesis
2007
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University of Cape Town
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Abstract
The increasing diversity of HIV-1 in different geographic regions presents a challenge for the development of an HIV/AIDS vaccine. Even if proven effective, the ability of a vaccine to have cross-subtype and intra-subtype protection remains an important question. The aim of the study was to investigate cross- and intra-clade T cell immune responses in HIV-1 subtype C-infected individuals. The objectives were to genetically characterise full length gag gene sequences from individuals chronically infected with HIV-1 and then assess the degree of cross-reactive immune responses in an ELlS pot assay using peptide reagents based on vaccine candidates.
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Includes bibliographical references (leaves 114-147).
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Zembe, L. 2007. Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa. University of Cape Town.