Physicochemical study of inclusion of drug molecules in cyclodextrins

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dc.contributor.advisorCaira, Mino Ren_ZA
dc.contributor.authorDodds, Devric Reginalden_ZA
dc.date.accessioned2014-11-18T18:28:07Z
dc.date.available2014-11-18T18:28:07Z
dc.date.issued1999en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractInclusion of drug molecules in cyclodextrins can significantly improve various aspects of their performance and has resulted in the use of cyclodextrins (CDs) for a wide variety of pharmaceutical applications. Consequently, the cyclodextrin inclusion of drugs has received great interest in the pharmaceutical and chemical fields. For this study the inclusion of nine pharmaceutical drugs with CDs was investigated in the solid state. The objectives of the study were i.) the preparation, ii.) determination of the chemical composition, iii.) analysis of thermal behaviour and iv.) investigation of the solid state features of the complexes. Ultraviolet spectrophotometry, elemental analysis and thermogravimetric analysis were the principal techniques used for determination of composition. Hot stage microscopy, differential scanning calorimetry and thermogravimetric analysis were the principal techniques used for the analysis of thermal behaviour. Single crystal x-ray diffraction and x-ray powder diffraction were the principal techniques used for investigation of structural features. This thesis reports the preparation by crystallisation from solution of eight beta cyclodextrin (β-CD) and four gamma cyclodextrin (γ-CD) inclusion complexes with selected drugs as guests, as well as the determination of their chemical compositions and analysis of their thermal behaviours. Investigation of the structural features of these complexes includes the determination of the crystal structures of five β-CD complexes and one γ-CD complex. The preparation of hydnoxypropyl-β-CD complexes by kneading and co-grinding is also reported.en_ZA
dc.identifier.apacitationDodds, D. R. (1999). <i>Physicochemical study of inclusion of drug molecules in cyclodextrins</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/9721en_ZA
dc.identifier.chicagocitationDodds, Devric Reginald. <i>"Physicochemical study of inclusion of drug molecules in cyclodextrins."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1999. http://hdl.handle.net/11427/9721en_ZA
dc.identifier.citationDodds, D. 1999. Physicochemical study of inclusion of drug molecules in cyclodextrins. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Dodds, Devric Reginald AB - Inclusion of drug molecules in cyclodextrins can significantly improve various aspects of their performance and has resulted in the use of cyclodextrins (CDs) for a wide variety of pharmaceutical applications. Consequently, the cyclodextrin inclusion of drugs has received great interest in the pharmaceutical and chemical fields. For this study the inclusion of nine pharmaceutical drugs with CDs was investigated in the solid state. The objectives of the study were i.) the preparation, ii.) determination of the chemical composition, iii.) analysis of thermal behaviour and iv.) investigation of the solid state features of the complexes. Ultraviolet spectrophotometry, elemental analysis and thermogravimetric analysis were the principal techniques used for determination of composition. Hot stage microscopy, differential scanning calorimetry and thermogravimetric analysis were the principal techniques used for the analysis of thermal behaviour. Single crystal x-ray diffraction and x-ray powder diffraction were the principal techniques used for investigation of structural features. This thesis reports the preparation by crystallisation from solution of eight beta cyclodextrin (β-CD) and four gamma cyclodextrin (γ-CD) inclusion complexes with selected drugs as guests, as well as the determination of their chemical compositions and analysis of their thermal behaviours. Investigation of the structural features of these complexes includes the determination of the crystal structures of five β-CD complexes and one γ-CD complex. The preparation of hydnoxypropyl-β-CD complexes by kneading and co-grinding is also reported. DA - 1999 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1999 T1 - Physicochemical study of inclusion of drug molecules in cyclodextrins TI - Physicochemical study of inclusion of drug molecules in cyclodextrins UR - http://hdl.handle.net/11427/9721 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9721
dc.identifier.vancouvercitationDodds DR. Physicochemical study of inclusion of drug molecules in cyclodextrins. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1999 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9721en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titlePhysicochemical study of inclusion of drug molecules in cyclodextrinsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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