Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana

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dc.contributor.advisorRybicki, Edward Pen_ZA
dc.contributor.advisorMeyers, Annen_ZA
dc.contributor.authorMbewana, Sandiswaen_ZA
dc.date.accessioned2017-09-28T05:29:08Z
dc.date.available2017-09-28T05:29:08Z
dc.date.issued2017en_ZA
dc.description.abstractRift Valley fever (RVF) is a haemorrhagic fever agent caused by an infection with an enveloped negative-stranded RNA Rift Valley fever virus (RVFV). It belongs to the genus Phlebovirus in the family Bunyaviridae. The virus is spread by infected mosquitoes and affects ruminants and humans, causing high numbers of neonatal fatalities in animals and occasional fatalities in humans. It is endemic to parts of Africa and the Arabian Peninsula, but is described as an emerging virus due to the wide range of mosquitoes that could spread the disease into non-endemic areas, posing serious health and agricultural problems. The disease can be prevented by vaccination, but there is currently no Food and Drug Administration-approved RVFV vaccine that can be used outside endemic areas, while there are two live attenuated vaccines available for use in endemic areas. These vaccines have the potential for reversion, and are therefore not recommended for use in countries where RVFV is not endemic. This indicates the need for more RVFV vaccine research and development. This work focused on the development of a RVFV vaccine candidate that would allow for differentiation between infected and vaccinated animals as well as humans.en_ZA
dc.identifier.apacitationMbewana, S. (2017). <i>Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/25446en_ZA
dc.identifier.chicagocitationMbewana, Sandiswa. <i>"Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2017. http://hdl.handle.net/11427/25446en_ZA
dc.identifier.citationMbewana, S. 2017. Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mbewana, Sandiswa AB - Rift Valley fever (RVF) is a haemorrhagic fever agent caused by an infection with an enveloped negative-stranded RNA Rift Valley fever virus (RVFV). It belongs to the genus Phlebovirus in the family Bunyaviridae. The virus is spread by infected mosquitoes and affects ruminants and humans, causing high numbers of neonatal fatalities in animals and occasional fatalities in humans. It is endemic to parts of Africa and the Arabian Peninsula, but is described as an emerging virus due to the wide range of mosquitoes that could spread the disease into non-endemic areas, posing serious health and agricultural problems. The disease can be prevented by vaccination, but there is currently no Food and Drug Administration-approved RVFV vaccine that can be used outside endemic areas, while there are two live attenuated vaccines available for use in endemic areas. These vaccines have the potential for reversion, and are therefore not recommended for use in countries where RVFV is not endemic. This indicates the need for more RVFV vaccine research and development. This work focused on the development of a RVFV vaccine candidate that would allow for differentiation between infected and vaccinated animals as well as humans. DA - 2017 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana TI - Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana UR - http://hdl.handle.net/11427/25446 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/25446
dc.identifier.vancouvercitationMbewana S. Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2017 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/25446en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMolecular and Cell Biologyen_ZA
dc.titleDevelopment of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamianaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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