Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract

Simple item page
dc.contributor.advisorPassmore, Jo-Annen_ZA
dc.contributor.authorSalkinder, Amy Leiaen_ZA
dc.date.accessioned2015-01-03T04:59:31Z
dc.date.available2015-01-03T04:59:31Z
dc.date.issued2010en_ZA
dc.descriptionIncludes bibliographical references (leaves 85-103).en_ZA
dc.description.abstractT helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to investigate the role of inflammatory/regulatory cytokines and bacterial burden in modulating Th17 cell frequencies in genital secretions and plasma.en_ZA
dc.identifier.apacitationSalkinder, A. L. (2010). <i>Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology. Retrieved from http://hdl.handle.net/11427/11067en_ZA
dc.identifier.chicagocitationSalkinder, Amy Leia. <i>"Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2010. http://hdl.handle.net/11427/11067en_ZA
dc.identifier.citationSalkinder, A. 2010. Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Salkinder, Amy Leia AB - T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to investigate the role of inflammatory/regulatory cytokines and bacterial burden in modulating Th17 cell frequencies in genital secretions and plasma. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract TI - Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract UR - http://hdl.handle.net/11427/11067 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11067
dc.identifier.vancouvercitationSalkinder AL. Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11067en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Microbiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Microbiologyen_ZA
dc.titleImpact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tracten_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2010_salkinder_a.pdf
Size:
1.76 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters