Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
Master Thesis
2010
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University of Cape Town
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Abstract
T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly. Depletion of Th17 cells from the gut mucosa during HIV infection has been suggested to contribute to elevated microbial translocation and immune activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to investigate the role of inflammatory/regulatory cytokines and bacterial burden in modulating Th17 cell frequencies in genital secretions and plasma.
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Includes bibliographical references (leaves 85-103).
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Salkinder, A. 2010. Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract. University of Cape Town.