Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses

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dc.contributor.authorDennis, Susan J
dc.contributor.authorO’Kennedy, Martha M
dc.contributor.authorRutkowska, Daria
dc.contributor.authorTsekoa, Tsepo
dc.contributor.authorLourens, Carina W
dc.contributor.authorHitzeroth, Inga I
dc.contributor.authorMeyers, Ann E
dc.contributor.authorRybicki, Edward P
dc.date.accessioned2018-10-15T14:25:43Z
dc.date.available2018-10-15T14:25:43Z
dc.date.issued2018-10-11
dc.date.updated2018-10-14T03:22:10Z
dc.description.abstractAbstract African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses.
dc.identifier.apacitationDennis, S. J., , Rutkowska, D., Tsekoa, T., Lourens, C. W., Hitzeroth, I. I., ... Rybicki, E. P. (2018). Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses. <i>Vet Res</i>, http://hdl.handle.net/11427/28928en_ZA
dc.identifier.chicagocitationDennis, Susan J, , Daria Rutkowska, Tsepo Tsekoa, Carina W Lourens, Inga I Hitzeroth, Ann E Meyers, and Edward P Rybicki "Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses." <i>Vet Res</i> (2018) http://hdl.handle.net/11427/28928en_ZA
dc.identifier.citationVeterinary Research. 2018 Oct 11;49(1):105
dc.identifier.ris TY - Journal Article AU - Dennis, Susan J AU - O’Kennedy, Martha M AU - Rutkowska, Daria AU - Tsekoa, Tsepo AU - Lourens, Carina W AU - Hitzeroth, Inga I AU - Meyers, Ann E AU - Rybicki, Edward P AB - Abstract African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses. DA - 2018-10-11 DB - OpenUCT DP - University of Cape Town J1 - Vet Res LK - https://open.uct.ac.za PB - University of Cape Town PY - 2018 T1 - Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses TI - Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses UR - http://hdl.handle.net/11427/28928 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13567-018-0600-4
dc.identifier.urihttp://hdl.handle.net/11427/28928
dc.identifier.vancouvercitationDennis SJ, , Rutkowska D, Tsekoa T, Lourens CW, Hitzeroth II, et al. Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses. Vet Res. 2018; http://hdl.handle.net/11427/28928.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rights.holderThe Author(s)
dc.sourceVet Res
dc.source.urihttps://veterinaryresearch.biomedcentral.com/
dc.titleSafety and immunogenicity of plant-produced African horse sickness virus-like particles in horses
dc.typeJournal Article
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uct.type.filetypeText
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