Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses
Journal Article
2018-10-11
Permanent link to this Item
Authors
Journal Title
Vet Res
Link to Journal
Journal ISSN
Volume Title
Publisher
BioMed Central
Publisher
University of Cape Town
Department
Faculty
License
Series
Abstract
Abstract
African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses.
Description
Reference:
Veterinary Research. 2018 Oct 11;49(1):105