50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens

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dc.contributor.authorSchwartz, Ilan Sen_ZA
dc.contributor.authorKenyon, Chrisen_ZA
dc.contributor.authorFeng, Peiyingen_ZA
dc.contributor.authorGovender, Nelesh Pen_ZA
dc.contributor.authorDukik, Karolinaen_ZA
dc.contributor.authorSigler, Lynneen_ZA
dc.contributor.authorJiang, Yanpingen_ZA
dc.contributor.authorStielow, J Benjaminen_ZA
dc.contributor.authorMuñoz, José Fen_ZA
dc.contributor.authorCuomo, Christina Aen_ZA
dc.contributor.authorBotha, Alfreden_ZA
dc.contributor.authorStchigel, Alberto Men_ZA
dc.contributor.authorDe Hoog, G Sybrenen_ZA
dc.date.accessioned2016-02-10T14:46:31Z
dc.date.available2016-02-10T14:46:31Z
dc.date.issued2015en_ZA
dc.description.abstractNew species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by producing a thermally-dependent, yeast-like phase rather than adiaspores, and by causing disseminated infections, predominantly in immunocompromised patients and often with high case-fatality rates. Such differences will be important for clinicians to consider in diagnosis and patient management, and for microbiologists who may encounter these fungi with increasing frequency.en_ZA
dc.identifier.apacitationSchwartz, I. S., Kenyon, C., Feng, P., Govender, N. P., Dukik, K., Sigler, L., ... De Hoog, G. S. (2015). 50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens. <i>PLoS One</i>, http://hdl.handle.net/11427/16950en_ZA
dc.identifier.chicagocitationSchwartz, Ilan S, Chris Kenyon, Peiying Feng, Nelesh P Govender, Karolina Dukik, Lynne Sigler, Yanping Jiang, et al "50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens." <i>PLoS One</i> (2015) http://hdl.handle.net/11427/16950en_ZA
dc.identifier.citationSchwartz, I. S., Kenyon, C., Feng, P., Govender, N. P., Dukik, K., Sigler, L., ... & Botha, A. (2015). 50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens. PLoS Pathog, 11(11), e1005198. doi:10.1371/journal.ppat.1005198en_ZA
dc.identifier.ris TY - Journal Article AU - Schwartz, Ilan S AU - Kenyon, Chris AU - Feng, Peiying AU - Govender, Nelesh P AU - Dukik, Karolina AU - Sigler, Lynne AU - Jiang, Yanping AU - Stielow, J Benjamin AU - Muñoz, José F AU - Cuomo, Christina A AU - Botha, Alfred AU - Stchigel, Alberto M AU - De Hoog, G Sybren AB - New species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by producing a thermally-dependent, yeast-like phase rather than adiaspores, and by causing disseminated infections, predominantly in immunocompromised patients and often with high case-fatality rates. Such differences will be important for clinicians to consider in diagnosis and patient management, and for microbiologists who may encounter these fungi with increasing frequency. DA - 2015 DB - OpenUCT DO - 10.1371/journal.ppat.1005198 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - 50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens TI - 50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens UR - http://hdl.handle.net/11427/16950 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1005198en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16950
dc.identifier.vancouvercitationSchwartz IS, Kenyon C, Feng P, Govender NP, Dukik K, Sigler L, et al. 50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens. PLoS One. 2015; http://hdl.handle.net/11427/16950.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2015 Schwartz et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherFungien_ZA
dc.subject.otherBiopsyen_ZA
dc.subject.otherFungal diseasesen_ZA
dc.subject.otherFungal structureen_ZA
dc.subject.otherYeast infectionsen_ZA
dc.subject.otherAnimal phylogeneticsen_ZA
dc.subject.otherFungal pathogensen_ZA
dc.subject.otherRespiratory infectionsen_ZA
dc.title50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogensen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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