50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens
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2015
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PLoS One
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Public Library of Science
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University of Cape Town
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Abstract
New species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by producing a thermally-dependent, yeast-like phase rather than adiaspores, and by causing disseminated infections, predominantly in immunocompromised patients and often with high case-fatality rates. Such differences will be important for clinicians to consider in diagnosis and patient management, and for microbiologists who may encounter these fungi with increasing frequency.
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Schwartz, I. S., Kenyon, C., Feng, P., Govender, N. P., Dukik, K., Sigler, L., ... & Botha, A. (2015). 50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens. PLoS Pathog, 11(11), e1005198. doi:10.1371/journal.ppat.1005198