Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene

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dc.contributor.advisorCaira, Mino Ren_ZA
dc.contributor.advisorHunter, Rogeren_ZA
dc.contributor.advisorBourne, Susanen_ZA
dc.contributor.authorSmith, Vincent Josephen_ZA
dc.date.accessioned2014-08-13T14:25:55Z
dc.date.available2014-08-13T14:25:55Z
dc.date.issued2004en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThis study describes the preparation and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD heptakis(2,6-di-O-methyl )-β-CD (DIMEB) and heptakls(2, 3, 6-tri-O-methyl )-β-CD (TRIMEB) to yield inclusion compounds α-CD·(E)-ajoene (1), α-CD·(Z)ajoene (2), β-CD·(E)-ajoene (3), β-CD·(Z)-ajoene (4), y-CD·(E)-ajoene (5), y-CD·(Z)-ajoene (6), DIMEB·(E)-ajoene (7), DIMEB·(Z)-ajoene (6), TRIMEB·(E)-ajoene·05H20 (9) and TRIMEB·(Z)-ajoene (10).en_ZA
dc.identifier.apacitationSmith, V. J. (2004). <i>Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6293en_ZA
dc.identifier.chicagocitationSmith, Vincent Joseph. <i>"Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2004. http://hdl.handle.net/11427/6293en_ZA
dc.identifier.citationSmith, V. 2004. Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Smith, Vincent Joseph AB - This study describes the preparation and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD heptakis(2,6-di-O-methyl )-β-CD (DIMEB) and heptakls(2, 3, 6-tri-O-methyl )-β-CD (TRIMEB) to yield inclusion compounds α-CD·(E)-ajoene (1), α-CD·(Z)ajoene (2), β-CD·(E)-ajoene (3), β-CD·(Z)-ajoene (4), y-CD·(E)-ajoene (5), y-CD·(Z)-ajoene (6), DIMEB·(E)-ajoene (7), DIMEB·(Z)-ajoene (6), TRIMEB·(E)-ajoene·05H20 (9) and TRIMEB·(Z)-ajoene (10). DA - 2004 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2004 T1 - Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene TI - Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene UR - http://hdl.handle.net/11427/6293 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6293
dc.identifier.vancouvercitationSmith VJ. Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2004 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6293en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titlePhysicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoeneen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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