Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene
Master Thesis
2004
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University of Cape Town
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Abstract
This study describes the preparation and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD heptakis(2,6-di-O-methyl )-β-CD (DIMEB) and heptakls(2, 3, 6-tri-O-methyl )-β-CD (TRIMEB) to yield inclusion compounds α-CD·(E)-ajoene (1), α-CD·(Z)ajoene (2), β-CD·(E)-ajoene (3), β-CD·(Z)-ajoene (4), y-CD·(E)-ajoene (5), y-CD·(Z)-ajoene (6), DIMEB·(E)-ajoene (7), DIMEB·(Z)-ajoene (6), TRIMEB·(E)-ajoene·05H20 (9) and TRIMEB·(Z)-ajoene (10).
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Smith, V. 2004. Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene. University of Cape Town.