Metal ion equilibria in biofluids - copper and rheumatoid arthritis

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dc.contributor.advisorGraham, Jacksonen_ZA
dc.contributor.authorKelly, Mark Josephen_ZA
dc.date.accessioned2014-11-11T20:18:31Z
dc.date.available2014-11-11T20:18:31Z
dc.date.issued1998en_ZA
dc.descriptionIncludes bibliographies.en_ZA
dc.description.abstractA computer model of blood plasma has been used to evaluate the factors affecting the ability of a ligand to increase the low molecular weight copper pool in vivo. The justification for using this speciation approach is based on the assumption that the low molecular weight copper complexes are important in the reduction of the inflammation associated with rheumatoid arthritis. Based on the results of the simulation, two novel ligands, 3,6,9, 12-tetra-azatetradecanedioic acid (dtda) and 3,6,9,-triazaundecanedioic acid (dtda) have been synthesised using a three step route. Multiple carboxylation was prevented by using the tosylate protecting group. The compounds were obtained in an overall yield of 14.7 and 29.0 , respectively, and characterised using n.m.r, l.R. and mass spectrometry. The stability constants of the complexes formed by these ligands with several metal-ions were determined using glass electrode potentiometry at 25°C and an ionic strength of 0.15 mol dm3. The metals used were the divalent ions of magnesium, calcium, manganese, cobalt, nickel, copper and zinc. The values determined followed the Irvine-Williams order of stability.en_ZA
dc.identifier.apacitationKelly, M. J. (1998). <i>Metal ion equilibria in biofluids - copper and rheumatoid arthritis</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/9584en_ZA
dc.identifier.chicagocitationKelly, Mark Joseph. <i>"Metal ion equilibria in biofluids - copper and rheumatoid arthritis."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1998. http://hdl.handle.net/11427/9584en_ZA
dc.identifier.citationKelly, M. 1998. Metal ion equilibria in biofluids - copper and rheumatoid arthritis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Kelly, Mark Joseph AB - A computer model of blood plasma has been used to evaluate the factors affecting the ability of a ligand to increase the low molecular weight copper pool in vivo. The justification for using this speciation approach is based on the assumption that the low molecular weight copper complexes are important in the reduction of the inflammation associated with rheumatoid arthritis. Based on the results of the simulation, two novel ligands, 3,6,9, 12-tetra-azatetradecanedioic acid (dtda) and 3,6,9,-triazaundecanedioic acid (dtda) have been synthesised using a three step route. Multiple carboxylation was prevented by using the tosylate protecting group. The compounds were obtained in an overall yield of 14.7 and 29.0 , respectively, and characterised using n.m.r, l.R. and mass spectrometry. The stability constants of the complexes formed by these ligands with several metal-ions were determined using glass electrode potentiometry at 25°C and an ionic strength of 0.15 mol dm3. The metals used were the divalent ions of magnesium, calcium, manganese, cobalt, nickel, copper and zinc. The values determined followed the Irvine-Williams order of stability. DA - 1998 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1998 T1 - Metal ion equilibria in biofluids - copper and rheumatoid arthritis TI - Metal ion equilibria in biofluids - copper and rheumatoid arthritis UR - http://hdl.handle.net/11427/9584 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9584
dc.identifier.vancouvercitationKelly MJ. Metal ion equilibria in biofluids - copper and rheumatoid arthritis. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1998 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9584en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleMetal ion equilibria in biofluids - copper and rheumatoid arthritisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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