Immunology and virology of HIV-1 infection in Cameroon

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dc.contributor.advisorBurgers, Wendyen_ZA
dc.contributor.advisorMartin, Darrenen_ZA
dc.contributor.authorTongo Passo, Aime Marcel Simonen_ZA
dc.date.accessioned2014-11-11T06:49:55Z
dc.date.available2014-11-11T06:49:55Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThis study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be crucial for dissecting the earliest evolutionary steps in the emergence of HIV-1 group M. In addition, the central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE peptides did not increase the breadth of T cell recognition in Abstract Page xvi this divergent population when compared to consensus M peptides. This underlies the need to include more mosaic peptides representing the variety of viruses that circulate in the region.en_ZA
dc.identifier.apacitationTongo Passo, A. M. S. (2014). <i>Immunology and virology of HIV-1 infection in Cameroon</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Virology. Retrieved from http://hdl.handle.net/11427/9521en_ZA
dc.identifier.chicagocitationTongo Passo, Aime Marcel Simon. <i>"Immunology and virology of HIV-1 infection in Cameroon."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2014. http://hdl.handle.net/11427/9521en_ZA
dc.identifier.citationTongo Passo, A. 2014. Immunology and virology of HIV-1 infection in Cameroon. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Tongo Passo, Aime Marcel Simon AB - This study confirms the widespread existence of highly divergent HIV lineages in Cameroon. While the genetic complexity of the Cameroonian HIV-1 epidemic has potentially serious implications for the design of biomedical interventions, detailed analyses of divergent Cameroonian HIV-1 group M lineages could be crucial for dissecting the earliest evolutionary steps in the emergence of HIV-1 group M. In addition, the central nature of HIV-1 consensus M sequences resulted in their broad recognition, but failed to identify highly immunodominant peptides between homogeneous and diverse HIV epidemics. Further refinement of these immunogens may contribute to the development of a globally relevant vaccine. Finally, the use of PTE peptides did not increase the breadth of T cell recognition in Abstract Page xvi this divergent population when compared to consensus M peptides. This underlies the need to include more mosaic peptides representing the variety of viruses that circulate in the region. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Immunology and virology of HIV-1 infection in Cameroon TI - Immunology and virology of HIV-1 infection in Cameroon UR - http://hdl.handle.net/11427/9521 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9521
dc.identifier.vancouvercitationTongo Passo AMS. Immunology and virology of HIV-1 infection in Cameroon. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9521en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleImmunology and virology of HIV-1 infection in Cameroonen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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