Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis

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dc.contributor.advisorRobson, Simonen_ZA
dc.contributor.advisorKirsch, Ralphen_ZA
dc.contributor.authorJackson, Shaun Williamen_ZA
dc.date.accessioned2014-11-10T09:04:03Z
dc.date.available2014-11-10T09:04:03Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractAngiogenesis refers to the growth and maturation of new vessels from pre-existing differentiated blood vessels. Co-ordination of angiogenic responses is crucial for a wide range of physiological and pathological processes. In particular, angiogenesis is hypothesized to facilitate tumour growth and promote metastasis, prompting research into anti-angiogenesis based cancer therapies. CD39/NTPDasel is an ectoenzyme expressed by vascular endothelium that hydrolyses extracellular nucleoside di- and triphosphates to the monophosphate derivatives. As such, this enzyme has a role in modulating endothelial responses to mucleotides that bind specific receptors termed Purinergic-type 2(P2) receptors. Since a number proliferation and migration in vitro, we propose that nucleotide signalling influences the process of angiogenesis in vivo.en_ZA
dc.identifier.apacitationJackson, S. W. (2006). <i>Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/9506en_ZA
dc.identifier.chicagocitationJackson, Shaun William. <i>"Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2006. http://hdl.handle.net/11427/9506en_ZA
dc.identifier.citationJackson, S. 2006. Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Jackson, Shaun William AB - Angiogenesis refers to the growth and maturation of new vessels from pre-existing differentiated blood vessels. Co-ordination of angiogenic responses is crucial for a wide range of physiological and pathological processes. In particular, angiogenesis is hypothesized to facilitate tumour growth and promote metastasis, prompting research into anti-angiogenesis based cancer therapies. CD39/NTPDasel is an ectoenzyme expressed by vascular endothelium that hydrolyses extracellular nucleoside di- and triphosphates to the monophosphate derivatives. As such, this enzyme has a role in modulating endothelial responses to mucleotides that bind specific receptors termed Purinergic-type 2(P2) receptors. Since a number proliferation and migration in vitro, we propose that nucleotide signalling influences the process of angiogenesis in vivo. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis TI - Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis UR - http://hdl.handle.net/11427/9506 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9506
dc.identifier.vancouvercitationJackson SW. Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9506en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titlePurinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesisen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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