Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis
Master Thesis
2006
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University of Cape Town
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Abstract
Angiogenesis refers to the growth and maturation of new vessels from pre-existing differentiated blood vessels. Co-ordination of angiogenic responses is crucial for a wide range of physiological and pathological processes. In particular, angiogenesis is hypothesized to facilitate tumour growth and promote metastasis, prompting research into anti-angiogenesis based cancer therapies. CD39/NTPDasel is an ectoenzyme expressed by vascular endothelium that hydrolyses extracellular nucleoside di- and triphosphates to the monophosphate derivatives. As such, this enzyme has a role in modulating endothelial responses to mucleotides that bind specific receptors termed Purinergic-type 2(P2) receptors. Since a number proliferation and migration in vitro, we propose that nucleotide signalling influences the process of angiogenesis in vivo.
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Jackson, S. 2006. Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis. University of Cape Town.