Rationalising the effect of guanine-based Ricin inhibitors using computer simulations

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dc.contributor.advisorNaidoo, Kevin Jen_ZA
dc.contributor.authorJayakody, Ranga Sen_ZA
dc.date.accessioned2014-08-13T14:26:36Z
dc.date.available2014-08-13T14:26:36Z
dc.date.issued2008en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (leaves 99-101).en_ZA
dc.description.abstractfor humans.This has lead to its use as a biological weapon and a therapeutic agent. the reaction mechanism of ricin is not known and so rational design is limited, resulting in no effective inhibitor being found for this enzyme. An important step towards understanding the reaction mechanism and the design of effective inhibitors is the complete understanding of the binding pocket and the mode/nature of binding ligands to the protein. In this thesis computational methods were used to rationalise the effect of selected ricin inhibitors.en_ZA
dc.identifier.apacitationJayakody, R. S. (2008). <i>Rationalising the effect of guanine-based Ricin inhibitors using computer simulations</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6315en_ZA
dc.identifier.chicagocitationJayakody, Ranga S. <i>"Rationalising the effect of guanine-based Ricin inhibitors using computer simulations."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2008. http://hdl.handle.net/11427/6315en_ZA
dc.identifier.citationJayakody, R. 2008. Rationalising the effect of guanine-based Ricin inhibitors using computer simulations. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Jayakody, Ranga S AB - for humans.This has lead to its use as a biological weapon and a therapeutic agent. the reaction mechanism of ricin is not known and so rational design is limited, resulting in no effective inhibitor being found for this enzyme. An important step towards understanding the reaction mechanism and the design of effective inhibitors is the complete understanding of the binding pocket and the mode/nature of binding ligands to the protein. In this thesis computational methods were used to rationalise the effect of selected ricin inhibitors. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Rationalising the effect of guanine-based Ricin inhibitors using computer simulations TI - Rationalising the effect of guanine-based Ricin inhibitors using computer simulations UR - http://hdl.handle.net/11427/6315 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6315
dc.identifier.vancouvercitationJayakody RS. Rationalising the effect of guanine-based Ricin inhibitors using computer simulations. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6315en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleRationalising the effect of guanine-based Ricin inhibitors using computer simulationsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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