Rationalising the effect of guanine-based Ricin inhibitors using computer simulations

Master Thesis

2008

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http://hdl.handle.net/11427/6315
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thesis_sci_2008_jayakody_r_opd (1).pdf (5.11 MB)
Authors
Jayakody, Ranga S
Supervisors
Naidoo, Kevin J
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University of Cape Town

Department
Department of Chemistry
Faculty
Faculty of Science
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Abstract
for humans.This has lead to its use as a biological weapon and a therapeutic agent. the reaction mechanism of ricin is not known and so rational design is limited, resulting in no effective inhibitor being found for this enzyme. An important step towards understanding the reaction mechanism and the design of effective inhibitors is the complete understanding of the binding pocket and the mode/nature of binding ligands to the protein. In this thesis computational methods were used to rationalise the effect of selected ricin inhibitors.
Description

Includes abstract.


Includes bibliographical references (leaves 99-101).

Keywords
Chemistry

Reference:

Jayakody, R. 2008. Rationalising the effect of guanine-based Ricin inhibitors using computer simulations. University of Cape Town.

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