Some factors regulating albumin catabolism and synthesis

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dc.contributor.advisorBrock, J Fen_ZA
dc.contributor.authorHoffenberg, Raymonden_ZA
dc.date.accessioned2017-12-14T14:21:11Z
dc.date.available2017-12-14T14:21:11Z
dc.date.issued1968en_ZA
dc.description.abstractHypoalbuminaemia is an essential accompaniment of protein malnutrition. Yet the level of plasma albumin is usually regarded as a relatively crude reflection of a patient's nutritional status, reduction occurring only after prolonged or severe inadequacy of dietary protein. Brock recognized that a marginal degree of hypoalbuminaemia might be evidence of impending or early deficiency, and suggested that minor grades of "protein subnutrition" could conceivably exist with serum albumin levels still within the normal range. The work reported in this thesis developed originally out of an attempt to explore this possibility, and to characterize some of the changes in albumin metabolism that followed mild or early experimental protein deprivation in man and rabbits. Dynamic studies using albumin labelled with radioactive iodine revealed evidence of early adaptational changes, possibly occurring before alteration in the plasma albumin levels. While these studies shed some light on the response of albumin metabolism to experimental depletion, they failed to provide the hoped-for means by which subclinical protein malnutrition could be detected. From this work, however, it was but a short conceptual jump to the general problem of albumin homeostasis, a consideration of which forms the basis of this thesis. The first approach was a study of changes in albumin synthesis and catabolism in rabbits following limitation of dietary protein intake. Adaptive responses were then investigated in animals, provided with normal protein diets, after protein depletion induced by an alternative method - plasmapheresis - and, finally, after intravenous infusion of albumin solutions. Based on these and reported results, a tentative hypothesis has been adduced to account for the body's adaptation to variation in the plasma albumin pool, brought about by experimental manipulation or occurring spontaneously in disease.en_ZA
dc.identifier.apacitationHoffenberg, R. (1968). <i>Some factors regulating albumin catabolism and synthesis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/26675en_ZA
dc.identifier.chicagocitationHoffenberg, Raymond. <i>"Some factors regulating albumin catabolism and synthesis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1968. http://hdl.handle.net/11427/26675en_ZA
dc.identifier.citationHoffenberg, R. 1968. Some factors regulating albumin catabolism and synthesis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Hoffenberg, Raymond AB - Hypoalbuminaemia is an essential accompaniment of protein malnutrition. Yet the level of plasma albumin is usually regarded as a relatively crude reflection of a patient's nutritional status, reduction occurring only after prolonged or severe inadequacy of dietary protein. Brock recognized that a marginal degree of hypoalbuminaemia might be evidence of impending or early deficiency, and suggested that minor grades of "protein subnutrition" could conceivably exist with serum albumin levels still within the normal range. The work reported in this thesis developed originally out of an attempt to explore this possibility, and to characterize some of the changes in albumin metabolism that followed mild or early experimental protein deprivation in man and rabbits. Dynamic studies using albumin labelled with radioactive iodine revealed evidence of early adaptational changes, possibly occurring before alteration in the plasma albumin levels. While these studies shed some light on the response of albumin metabolism to experimental depletion, they failed to provide the hoped-for means by which subclinical protein malnutrition could be detected. From this work, however, it was but a short conceptual jump to the general problem of albumin homeostasis, a consideration of which forms the basis of this thesis. The first approach was a study of changes in albumin synthesis and catabolism in rabbits following limitation of dietary protein intake. Adaptive responses were then investigated in animals, provided with normal protein diets, after protein depletion induced by an alternative method - plasmapheresis - and, finally, after intravenous infusion of albumin solutions. Based on these and reported results, a tentative hypothesis has been adduced to account for the body's adaptation to variation in the plasma albumin pool, brought about by experimental manipulation or occurring spontaneously in disease. DA - 1968 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1968 T1 - Some factors regulating albumin catabolism and synthesis TI - Some factors regulating albumin catabolism and synthesis UR - http://hdl.handle.net/11427/26675 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26675
dc.identifier.vancouvercitationHoffenberg R. Some factors regulating albumin catabolism and synthesis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 1968 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26675en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherProtein - Metabolismen_ZA
dc.subject.otherAlbuminsen_ZA
dc.titleSome factors regulating albumin catabolism and synthesisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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