Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species

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dc.contributor.advisorMeissner, Peteren_ZA
dc.contributor.advisorCorrigall, Anneen_ZA
dc.contributor.authorSiziba, Kwanele Bennetten_ZA
dc.date.accessioned2014-07-29T09:10:30Z
dc.date.available2014-07-29T09:10:30Z
dc.date.issued2000en_ZA
dc.descriptionBibliography: leaves 163-203.
dc.description.abstractThis work involved the characterisation of protoporphyrinogen oxidase (PPO), the penultimate enzyme in haem biosynthesis, from Bacillus subtilis, Myxococcus xanthus, and human. A defect in human PPO causes variegate porphyria, an autosomal dominant disorder characterised by skin photosensitivity and propensity towards acute neurovisceral crises. At the beginning of this project little information was available on the kinetic and biophysical properties of isolated PPOs due largely to difficulties associated with their purification from natural sources.en_ZA
dc.identifier.apacitationSiziba, K. B. (2000). <i>Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3464en_ZA
dc.identifier.chicagocitationSiziba, Kwanele Bennett. <i>"Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2000. http://hdl.handle.net/11427/3464en_ZA
dc.identifier.citationSiziba, K. 2000. Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Siziba, Kwanele Bennett AB - This work involved the characterisation of protoporphyrinogen oxidase (PPO), the penultimate enzyme in haem biosynthesis, from Bacillus subtilis, Myxococcus xanthus, and human. A defect in human PPO causes variegate porphyria, an autosomal dominant disorder characterised by skin photosensitivity and propensity towards acute neurovisceral crises. At the beginning of this project little information was available on the kinetic and biophysical properties of isolated PPOs due largely to difficulties associated with their purification from natural sources. DA - 2000 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2000 T1 - Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species TI - Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species UR - http://hdl.handle.net/11427/3464 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3464
dc.identifier.vancouvercitationSiziba KB. Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2000 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3464en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleExpression, purification and characterisation of protoporphyrinogen oxidases from diverse speciesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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