Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape

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dc.contributor.advisorFlisher, Alan Jen_ZA
dc.contributor.advisorStein, Dan Jen_ZA
dc.contributor.authorJoska, John Antonen_ZA
dc.date.accessioned2015-01-05T06:59:42Z
dc.date.available2015-01-05T06:59:42Z
dc.date.issued2010en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractHIV-associated neurocognitive disorders (HAND) remain prevalent in the era of highly active anti-retroviral therapy (HAART). The aim of the study was to investigate whether HAND are as prevalent in South Africa as in other regions, and whether individuals with HAND in South Africa will respond to HAART. The literature was reviewed to elucidate potential mechanisms of the development of HIV-associated dementia (HAD), the most severe form of HAND, and to establish the effect that HAART has exerted on HAND across diverse studies. A prospective clinical cohort study was initiated in Cape Town, comprising 170 participants. The reviewed literature suggests that HAD is likely mediated by a range of HIV-related factors (including possible difference in HIV sub-type) and host-related factors.en_ZA
dc.identifier.apacitationJoska, J. A. (2010). <i>Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health. Retrieved from http://hdl.handle.net/11427/11363en_ZA
dc.identifier.chicagocitationJoska, John Anton. <i>"Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health, 2010. http://hdl.handle.net/11427/11363en_ZA
dc.identifier.citationJoska, J. 2010. Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Joska, John Anton AB - HIV-associated neurocognitive disorders (HAND) remain prevalent in the era of highly active anti-retroviral therapy (HAART). The aim of the study was to investigate whether HAND are as prevalent in South Africa as in other regions, and whether individuals with HAND in South Africa will respond to HAART. The literature was reviewed to elucidate potential mechanisms of the development of HIV-associated dementia (HAD), the most severe form of HAND, and to establish the effect that HAART has exerted on HAND across diverse studies. A prospective clinical cohort study was initiated in Cape Town, comprising 170 participants. The reviewed literature suggests that HAD is likely mediated by a range of HIV-related factors (including possible difference in HIV sub-type) and host-related factors. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape TI - Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape UR - http://hdl.handle.net/11427/11363 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11363
dc.identifier.vancouvercitationJoska JA. Neurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Cape. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11363en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Psychiatry and Mental Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPsychiatryen_ZA
dc.titleNeurocognitive disorders in young adults commencing highly active anti-retroviral treatment in the Western Capeen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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