Expression and functional role of cyclooxygenase enzymes in cervical carcinoma

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dc.contributor.advisorKatz, Ariehen_ZA
dc.contributor.advisorJabbour, Henryen_ZA
dc.contributor.authorSales, Kurt Jasonen_ZA
dc.date.accessioned2014-07-28T14:55:58Z
dc.date.available2014-07-28T14:55:58Z
dc.date.issued2001en_ZA
dc.descriptionBibliography: leaves 133-156.
dc.description.abstractCervical cancer is considered an important clinical problem in sub-Saharan Africa. Recent studies have suggested that epithelial tumors may be regulated by cyclooxygenase enzyme products. The purpose of this thesis was to determine the expression, localisation and possible functional role of cyclooxygenase enzymes in cervical carcinomas. The initial aim of the study was to determine whether cyclooxygenase-1 and cyclooxygenase-2 expession and prostglandin E₂ synthesis are up-regulated in cervical cancers. Real-time quantitative reverse-transcriptase polymerase chain reaction and Western blot analysis confirmed cyclooxygenase-1 and cyclooxygenase-2 ribonucleic acid and protein expression in all cases of squamous cell carcinoma and adenocarcinoma investigated. In contrast, minimal expression of cyclooxygenase-1 or cyclooxygenase-2 was detected in histologically normal cervix. Immunohistochemical analyses localised the site of cyclooxygenase-1 and cyclooxygenase-2 expression and prostaglandin E₂ synthesis to neoplastic epithelial cells of all squamous cell carcinomas and adenocarcinomas studied.en_ZA
dc.identifier.apacitationSales, K. J. (2001). <i>Expression and functional role of cyclooxygenase enzymes in cervical carcinoma</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/3149en_ZA
dc.identifier.chicagocitationSales, Kurt Jason. <i>"Expression and functional role of cyclooxygenase enzymes in cervical carcinoma."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2001. http://hdl.handle.net/11427/3149en_ZA
dc.identifier.citationSales, K. 2001. Expression and functional role of cyclooxygenase enzymes in cervical carcinoma. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Sales, Kurt Jason AB - Cervical cancer is considered an important clinical problem in sub-Saharan Africa. Recent studies have suggested that epithelial tumors may be regulated by cyclooxygenase enzyme products. The purpose of this thesis was to determine the expression, localisation and possible functional role of cyclooxygenase enzymes in cervical carcinomas. The initial aim of the study was to determine whether cyclooxygenase-1 and cyclooxygenase-2 expession and prostglandin E₂ synthesis are up-regulated in cervical cancers. Real-time quantitative reverse-transcriptase polymerase chain reaction and Western blot analysis confirmed cyclooxygenase-1 and cyclooxygenase-2 ribonucleic acid and protein expression in all cases of squamous cell carcinoma and adenocarcinoma investigated. In contrast, minimal expression of cyclooxygenase-1 or cyclooxygenase-2 was detected in histologically normal cervix. Immunohistochemical analyses localised the site of cyclooxygenase-1 and cyclooxygenase-2 expression and prostaglandin E₂ synthesis to neoplastic epithelial cells of all squamous cell carcinomas and adenocarcinomas studied. DA - 2001 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2001 T1 - Expression and functional role of cyclooxygenase enzymes in cervical carcinoma TI - Expression and functional role of cyclooxygenase enzymes in cervical carcinoma UR - http://hdl.handle.net/11427/3149 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3149
dc.identifier.vancouvercitationSales KJ. Expression and functional role of cyclooxygenase enzymes in cervical carcinoma. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2001 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3149en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleExpression and functional role of cyclooxygenase enzymes in cervical carcinomaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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