Structure and metabolism of bovine aortic proteoglycans

dc.contributor.advisorScott-Burden, Timothy
dc.contributor.authorMurray, Eileen
dc.date.accessioned2026-02-11T12:08:50Z
dc.date.available2026-02-11T12:08:50Z
dc.date.issued1983
dc.date.updated2026-02-11T12:04:29Z
dc.description.abstractAlthough a number of studies of arterial glycosaminoglycans have been carried out, there is comparatively little information available regarding the native state in which these glycosaminoglycans occur, namely covalently bound to protein to form proteoglycans. There are numerous factors that make arterial proteoglycans difficult to study, such as their relatively low concentration in the tissue a s compared to cartilaginous tissue, and their association with the fibrous elements of the matrix which make quantitative extraction difficult. In recent years reports of characterizations of arterial proteoglycans have appeared in the literature but they differ markedly in several respects. In order to minimize such variables, proteoglycans isolated from pure medial tissue of bovine aortas from different age groups have been studied. Isolation of these proteoglycans was carried out essentially as described for their counterparts from cartilage. Furthermore, proteoglycans have been isolated from a cultured clonal line of foetal bovine aortic medial smooth muscle cells and comparison s made between the two sources of material in terms of their proteoglycan monomer size and glycosaminoglycan composition.
dc.identifier.apacitationMurray, E. (1983). <i>Structure and metabolism of bovine aortic proteoglycans</i>. (). University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering. Retrieved from http://hdl.handle.net/11427/42831en_ZA
dc.identifier.chicagocitationMurray, Eileen. <i>"Structure and metabolism of bovine aortic proteoglycans."</i> ., University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering, 1983. http://hdl.handle.net/11427/42831en_ZA
dc.identifier.citationMurray, E. 1983. Structure and metabolism of bovine aortic proteoglycans. . University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering. http://hdl.handle.net/11427/42831en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Murray, Eileen AB - Although a number of studies of arterial glycosaminoglycans have been carried out, there is comparatively little information available regarding the native state in which these glycosaminoglycans occur, namely covalently bound to protein to form proteoglycans. There are numerous factors that make arterial proteoglycans difficult to study, such as their relatively low concentration in the tissue a s compared to cartilaginous tissue, and their association with the fibrous elements of the matrix which make quantitative extraction difficult. In recent years reports of characterizations of arterial proteoglycans have appeared in the literature but they differ markedly in several respects. In order to minimize such variables, proteoglycans isolated from pure medial tissue of bovine aortas from different age groups have been studied. Isolation of these proteoglycans was carried out essentially as described for their counterparts from cartilage. Furthermore, proteoglycans have been isolated from a cultured clonal line of foetal bovine aortic medial smooth muscle cells and comparison s made between the two sources of material in terms of their proteoglycan monomer size and glycosaminoglycan composition. DA - 1983 DB - OpenUCT DP - University of Cape Town KW - arterial glycosaminoglycans KW - proteoglycans LK - https://open.uct.ac.za PB - University of Cape Town PY - 1983 T1 - Structure and metabolism of bovine aortic proteoglycans TI - Structure and metabolism of bovine aortic proteoglycans UR - http://hdl.handle.net/11427/42831 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/42831
dc.identifier.vancouvercitationMurray E. Structure and metabolism of bovine aortic proteoglycans. []. University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering, 1983 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/42831en_ZA
dc.language.isoen
dc.language.rfc3066eng
dc.publisher.departmentDivision of Biomedical Engineering
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subjectarterial glycosaminoglycans
dc.subjectproteoglycans
dc.titleStructure and metabolism of bovine aortic proteoglycans
dc.typeThesis / Dissertation
dc.type.qualificationlevelDoctoral
dc.type.qualificationlevelPhD
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