Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity

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dc.contributor.advisorJames, Michael F Men_ZA
dc.contributor.authorReed, Anthony Raddonen_ZA
dc.date.accessioned2018-01-25T13:57:23Z
dc.date.available2018-01-25T13:57:23Z
dc.date.issued1998en_ZA
dc.description.abstractThe results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine.en_ZA
dc.identifier.apacitationReed, A. R. (1998). <i>Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Anaesthesia. Retrieved from http://hdl.handle.net/11427/26985en_ZA
dc.identifier.chicagocitationReed, Anthony Raddon. <i>"Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Anaesthesia, 1998. http://hdl.handle.net/11427/26985en_ZA
dc.identifier.citationReed, A. 1998. Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Reed, Anthony Raddon AB - The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine. DA - 1998 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1998 T1 - Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity TI - Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity UR - http://hdl.handle.net/11427/26985 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26985
dc.identifier.vancouvercitationReed AR. Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Anaesthesia, 1998 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26985en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Anaesthesiaen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAnaesthesiaen_ZA
dc.titleMagnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicityen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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