Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity

Reed, Anthony Raddon

Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity

Master Thesis

1998

Publisher

University of Cape Town

Department

Department of Anaesthesia

Faculty

Faculty of Health Sciences

Abstract

The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine.

Keywords

Anaesthesia

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