An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines
Master Thesis
2013
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University of Cape Town
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Abstract
Previous studies from the HIV Vaccine Development Group at the University of Cape Town have reported that immunisation with recombinant modified vaccinia Ankara (SAAVI MVA-C) or DNA prime and Pr55 Gag virus-like particle (VLP) boost based on HIV-1 subtype C are able to successfully induce vaccine specific responses in Chacma baboons. The aim of the current study was to characterise the T cell memory phenotype distribution in peripheral mononuclear cells (PBMCs) isolated from Chacma baboons vaccinated with SAAVI MVA-C/VLP and DNA/VLP prime-boost vaccination regimens by flow cytometry.
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Singh, V. 2013. An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines. University of Cape Town.