Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study

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dc.contributor.authorKaze, Francoisen_ZA
dc.contributor.authorHalle, Marie-Patriceen_ZA
dc.contributor.authorMopa, Hermineen_ZA
dc.contributor.authorAshuntantang, Gloriaen_ZA
dc.contributor.authorFouda, Hermineen_ZA
dc.contributor.authorNgogang, Jeanneen_ZA
dc.contributor.authorKengne, Andre-Pascalen_ZA
dc.date.accessioned2015-12-07T08:52:11Z
dc.date.available2015-12-07T08:52:11Z
dc.date.issued2015en_ZA
dc.description.abstractBACKGROUND: Chronic kidney disease (CKD) is a major threat to the health of people of African ancestry. We assessed the prevalence and risk factors of CKD among adults in urban Cameroon. METHODS: This was a cross-sectional study of two months duration (March to April 2013) conducted at the Cite des Palmiers health district in the Littoral region of Cameroon. A multistage cluster sampling approach was applied. Estimated glomerular filtration rate (eGFR) was based on the Cockcroft-Gault (CG), the four-variable Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Logistic regression models were used to investigate the predictors of CKD. RESULTS: In the 500 participants with a mean age of 45.3+/-13.2years included, we observed a high prevalence of overweight and obesity (60.4%), hypertension (38.6%) and diabetes (2.8%). The mean eGFR was 93.7+/-24.9, 97.8+/-24.9 and 99.2+/-31.4ml/min respectively with the MDRD, CG and CKD-EPI equations. The prevalence of albuminuria was 7.2% while the prevalence of decreased GFR (eGFR<60ml/min) and CKD (any albuminuria and/or eGFR<60ml/min) was 4.4 and 11% with MDRD, 5.4 and 14.2% with CG, and 8.8 and 10% with CKD-EPI. In age and sex adjusted logistic regression models, advanced age, known hypertension and diabetes mellitus, increasing body mass index and overweight/obesity were the predictors of albuminuria, decreased GFR and CKD according to various estimators. CONCLUSION: There is a high prevalence of CKD in urban adults Cameroonian, driven essentially by the commonest risk factors for CKD.en_ZA
dc.identifier.apacitationKaze, F., Halle, M., Mopa, H., Ashuntantang, G., Fouda, H., Ngogang, J., & Kengne, A. (2015). Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study. <i>BMC Nephrology</i>, http://hdl.handle.net/11427/15651en_ZA
dc.identifier.chicagocitationKaze, Francois, Marie-Patrice Halle, Hermine Mopa, Gloria Ashuntantang, Hermine Fouda, Jeanne Ngogang, and Andre-Pascal Kengne "Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study." <i>BMC Nephrology</i> (2015) http://hdl.handle.net/11427/15651en_ZA
dc.identifier.citationKaze, F. F., Halle, M. P., Mopa, H. T., Ashuntantang, G., Fouda, H., Ngogang, J., & Kengne, A. P. (2015). Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study. BMC nephrology, 16(1), 96.en_ZA
dc.identifier.ris TY - Journal Article AU - Kaze, Francois AU - Halle, Marie-Patrice AU - Mopa, Hermine AU - Ashuntantang, Gloria AU - Fouda, Hermine AU - Ngogang, Jeanne AU - Kengne, Andre-Pascal AB - BACKGROUND: Chronic kidney disease (CKD) is a major threat to the health of people of African ancestry. We assessed the prevalence and risk factors of CKD among adults in urban Cameroon. METHODS: This was a cross-sectional study of two months duration (March to April 2013) conducted at the Cite des Palmiers health district in the Littoral region of Cameroon. A multistage cluster sampling approach was applied. Estimated glomerular filtration rate (eGFR) was based on the Cockcroft-Gault (CG), the four-variable Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Logistic regression models were used to investigate the predictors of CKD. RESULTS: In the 500 participants with a mean age of 45.3+/-13.2years included, we observed a high prevalence of overweight and obesity (60.4%), hypertension (38.6%) and diabetes (2.8%). The mean eGFR was 93.7+/-24.9, 97.8+/-24.9 and 99.2+/-31.4ml/min respectively with the MDRD, CG and CKD-EPI equations. The prevalence of albuminuria was 7.2% while the prevalence of decreased GFR (eGFR<60ml/min) and CKD (any albuminuria and/or eGFR<60ml/min) was 4.4 and 11% with MDRD, 5.4 and 14.2% with CG, and 8.8 and 10% with CKD-EPI. In age and sex adjusted logistic regression models, advanced age, known hypertension and diabetes mellitus, increasing body mass index and overweight/obesity were the predictors of albuminuria, decreased GFR and CKD according to various estimators. CONCLUSION: There is a high prevalence of CKD in urban adults Cameroonian, driven essentially by the commonest risk factors for CKD. DA - 2015 DB - OpenUCT DO - 10.1186/s12882-015-0102-9 DP - University of Cape Town J1 - BMC Nephrology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study TI - Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study UR - http://hdl.handle.net/11427/15651 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15651
dc.identifier.urihttp://dx.doi.org/10.1186/s12882-015-0102-9
dc.identifier.vancouvercitationKaze F, Halle M, Mopa H, Ashuntantang G, Fouda H, Ngogang J, et al. Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study. BMC Nephrology. 2015; http://hdl.handle.net/11427/15651.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2015 Kaze et al.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourceBMC Nephrologyen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcnephrol/en_ZA
dc.subject.otherChronic kidney disease (CKD)en_ZA
dc.subject.otherAfrican ancestryen_ZA
dc.titlePrevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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