The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells

Doctoral Thesis

2011

Permanent link to this Item
http://hdl.handle.net/11427/10861
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thesis_hsf_2011_rose_b.pdf (2.55 MB)
Authors
Rose, Beverley Ann
Supervisors
Parker, Iqbal
Leaner, Virna
Journal Title
Link to Journal
Journal ISSN
Volume Title
Publisher
Publisher

University of Cape Town

Department
Division of Medical Biochemistry
Faculty
Faculty of Health Sciences
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Abstract
Recent studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion. Stromal fibroblasts produce most of the extracellular matrix (ECM) components found in the stroma, including type I collagen. Previous in vivo studies in our laboratory have shown that type I collagen mRNA levels are decreased in stage II and III breast tumour tissue compared to adjacent normal tissue.
Description

Includes abstract.


Includes bibliographical references (leaves 110-135).

Keywords
Medical Biochemistry

Reference:

Rose, B. 2011. The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells. University of Cape Town.

Collections
PhD / Doctoral