Utero-placental blood flow in hypertensive pregnancy and the effect of nifedipine administration
Master Thesis
1987
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University of Cape Town
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Abstract
Nifedipine, in a 5mg sublingual acute administration, causes a significant fall in the systolic, diastolic and mean arterial pressure in a mixed group of pregnant hypertensives. A concurrent, significant rise in the pulse rate was seen. The utero-placental blood flow index, which is a measure of utero-placental blood flow, was not significantly reduced following the administration of Nifedipine or a placebo. The utero-placental blood flow index was found to be a consistent measure of utero-placental blood flow in resting patients. In the absence of serious side-effects it can be concluded that Nifedipine is a safe therapy in the acute treatment of hypertensive states in pregnancy.
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Lindow, S. 1987. Utero-placental blood flow in hypertensive pregnancy and the effect of nifedipine administration. University of Cape Town.