A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)

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dc.contributor.advisorDouglass, Nicolaen_ZA
dc.contributor.advisorWilliamson, Anna-Liseen_ZA
dc.contributor.authorPaulsen, Janisen_ZA
dc.date.accessioned2014-07-28T08:21:48Z
dc.date.available2014-07-28T08:21:48Z
dc.date.issued2007en_ZA
dc.descriptionIncludes bibliographical references (leaves 96-114).
dc.description.abstractCowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical pathways of complement activation by binding to the proteins C3 and C4, thereby preventing complementmediated opsonisation of virus, antibody-mediated lysis of infected cells and migration of inflammatory cells into the site of infection. VCP also possesses heparin binding sites.en_ZA
dc.identifier.apacitationPaulsen, J. (2007). <i>A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Virology. Retrieved from http://hdl.handle.net/11427/2733en_ZA
dc.identifier.chicagocitationPaulsen, Janis. <i>"A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2007. http://hdl.handle.net/11427/2733en_ZA
dc.identifier.citationPaulsen, J. 2007. A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP). University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Paulsen, Janis AB - Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical pathways of complement activation by binding to the proteins C3 and C4, thereby preventing complementmediated opsonisation of virus, antibody-mediated lysis of infected cells and migration of inflammatory cells into the site of infection. VCP also possesses heparin binding sites. DA - 2007 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP) TI - A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP) UR - http://hdl.handle.net/11427/2733 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/2733
dc.identifier.vancouvercitationPaulsen J. A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP). [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2007 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/2733en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Virologyen_ZA
dc.titleA comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)en_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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