A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)

Master Thesis

2007

Permanent link to this Item
http://hdl.handle.net/11427/2733
Files
thesis_hsf_2007_paulsen_j.pdf (26.78 MB)
Authors
Paulsen, Janis
Supervisors
Douglass, Nicola
Williamson, Anna-Lise
Journal Title
Link to Journal
Journal ISSN
Volume Title
Publisher
Publisher

University of Cape Town

Department
Division of Virology
Faculty
Faculty of Health Sciences
License
Series
Abstract
Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical pathways of complement activation by binding to the proteins C3 and C4, thereby preventing complementmediated opsonisation of virus, antibody-mediated lysis of infected cells and migration of inflammatory cells into the site of infection. VCP also possesses heparin binding sites.
Description

Includes bibliographical references (leaves 96-114).

Keywords
Medical Virology

Reference:

Paulsen, J. 2007. A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP). University of Cape Town.

Collections
Masters