Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis

Simple item page
dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.authorHoving, J Claireen_ZA
dc.date.accessioned2014-07-28T14:57:25Z
dc.date.available2014-07-28T14:57:25Z
dc.date.issued2010en_ZA
dc.description.abstractUlcerative colitis (UC) is a heterogeneous inflammatory bowel disease (IBD) associated with chronic inflammation of the gastrointestinal tract. Characterized by genetic and immunological abnormalities, UC has overly aggressive T-cell responses to commensal bacteria eventually leading to disease pathology. UC is distinguished from Crohn's disease, another form of IBD, in that it is driven by a T helper type 2 (Th2) immune response. Oxazolone-induced colitis is a mouse model resembling UC presenting with inflammation limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines interleukin (IL)-4 and IL-13 are associated with the onset of oxazolone colitis and both signal through a common IL-4 receptor-alpha chain (IL-4R +-). Neutralizing these cytokines prevents or ameliorates disease significantly, while neutralizing IL-12 exacerbates disease symptoms. As many aspects of the mechanisms involving Th2 cytokines in colitis remain undefined, the aim of this study was to investigate the role of IL-4 and IL-13 and the receptors through which they signal in oxazolone-induced colitis. Previous studies have highlighted a role for IL-4 and IL-13 in mediating oxazolone colitis. We show that while IL-13-deficient BALB/c mice were protected from disease onset, IL-4R +- deficient BALB/c mice developed exacerbated disease symptoms.en_ZA
dc.identifier.apacitationHoving, J. C. (2010). <i>Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences. Retrieved from http://hdl.handle.net/11427/3164en_ZA
dc.identifier.chicagocitationHoving, J Claire. <i>"Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2010. http://hdl.handle.net/11427/3164en_ZA
dc.identifier.citationHoving, J. 2010. Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Hoving, J Claire AB - Ulcerative colitis (UC) is a heterogeneous inflammatory bowel disease (IBD) associated with chronic inflammation of the gastrointestinal tract. Characterized by genetic and immunological abnormalities, UC has overly aggressive T-cell responses to commensal bacteria eventually leading to disease pathology. UC is distinguished from Crohn's disease, another form of IBD, in that it is driven by a T helper type 2 (Th2) immune response. Oxazolone-induced colitis is a mouse model resembling UC presenting with inflammation limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines interleukin (IL)-4 and IL-13 are associated with the onset of oxazolone colitis and both signal through a common IL-4 receptor-alpha chain (IL-4R +-). Neutralizing these cytokines prevents or ameliorates disease significantly, while neutralizing IL-12 exacerbates disease symptoms. As many aspects of the mechanisms involving Th2 cytokines in colitis remain undefined, the aim of this study was to investigate the role of IL-4 and IL-13 and the receptors through which they signal in oxazolone-induced colitis. Previous studies have highlighted a role for IL-4 and IL-13 in mediating oxazolone colitis. We show that while IL-13-deficient BALB/c mice were protected from disease onset, IL-4R +- deficient BALB/c mice developed exacerbated disease symptoms. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis TI - Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis UR - http://hdl.handle.net/11427/3164 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3164
dc.identifier.vancouvercitationHoving JC. Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3164en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleInvestigating the role of IL-4/IL-13 and their receptors in ulcerative colitisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2010_hoving_jc.pdf
Size:
2.86 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
PhD / Doctoral