Complexation of divalent copper, zinc and calcium ions by phosphate esters in aqueous solution

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dc.contributor.advisorLinder, Peter Wen_ZA
dc.contributor.authorKramer, Ulrikeen_ZA
dc.date.accessioned2016-02-17T07:16:30Z
dc.date.available2016-02-17T07:16:30Z
dc.date.issued1988en_ZA
dc.description.abstractThe role of metal ions as catalysts for numerous biochemical reactions has been the subject of many investigations. One of the most important classes of ligands are phosphate esters. In this thesis I describe the investigation of some phosphate ester-metal ion equilibria. Formation constants for the complexation of p-nitrophenyl phosphate, phenyl phosphate, 1-naphthyl phosphate, α-D-glucose-1'-phosphate, glycerol-2-phosphate, methyl phosphate, 8-quinolyl phosphate, 8-quinolyl methyl phosphate, triphosphate and fluorotriphosphate with protons, copper, zinc and calcium ions were determined by potentiometry. In addition, the complexation of 1-naphthyl phosphate, 8-quinolyl phosphate and 8-quinolyl methyl phosphate with nickel and cobalt ions was also studied. Protonation enthalpies and copper complexation enthalpies of p-nitrophenyl phosphate, phenyl phosphate, 1-naphthyl phosphate, α-D-glucose-1'-phosphate, glycerol-2-phosphate and methyl phosphate were determined by calorimetry. A correlation between the nucleophilicity of the ester group and the magnitude of the stability constants of the proton, copper and zinc complexes of p-nitrophenyl phosphate, phenyl phosphate, 1-naphthyl phosphate, α-D-glucose-1'-phosphate, glycerol-2-phosphate and methyl phosphate is found and explained in terms of electronic induction effects, i.e. by polarisation of the phosphate oxygens by the ester group. The calorimetric results show that the desolvation of ligand and metal ion during the complexation plays an important role. The possibility of similar correlations for complexes of triphosphates is also discussed.en_ZA
dc.identifier.apacitationKramer, U. (1988). <i>Complexation of divalent copper, zinc and calcium ions by phosphate esters in aqueous solution</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/17083en_ZA
dc.identifier.chicagocitationKramer, Ulrike. <i>"Complexation of divalent copper, zinc and calcium ions by phosphate esters in aqueous solution."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1988. http://hdl.handle.net/11427/17083en_ZA
dc.identifier.citationKramer, U. 1988. Complexation of divalent copper, zinc and calcium ions by phosphate esters in aqueous solution. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Kramer, Ulrike AB - The role of metal ions as catalysts for numerous biochemical reactions has been the subject of many investigations. One of the most important classes of ligands are phosphate esters. In this thesis I describe the investigation of some phosphate ester-metal ion equilibria. Formation constants for the complexation of p-nitrophenyl phosphate, phenyl phosphate, 1-naphthyl phosphate, α-D-glucose-1'-phosphate, glycerol-2-phosphate, methyl phosphate, 8-quinolyl phosphate, 8-quinolyl methyl phosphate, triphosphate and fluorotriphosphate with protons, copper, zinc and calcium ions were determined by potentiometry. In addition, the complexation of 1-naphthyl phosphate, 8-quinolyl phosphate and 8-quinolyl methyl phosphate with nickel and cobalt ions was also studied. Protonation enthalpies and copper complexation enthalpies of p-nitrophenyl phosphate, phenyl phosphate, 1-naphthyl phosphate, α-D-glucose-1'-phosphate, glycerol-2-phosphate and methyl phosphate were determined by calorimetry. A correlation between the nucleophilicity of the ester group and the magnitude of the stability constants of the proton, copper and zinc complexes of p-nitrophenyl phosphate, phenyl phosphate, 1-naphthyl phosphate, α-D-glucose-1'-phosphate, glycerol-2-phosphate and methyl phosphate is found and explained in terms of electronic induction effects, i.e. by polarisation of the phosphate oxygens by the ester group. The calorimetric results show that the desolvation of ligand and metal ion during the complexation plays an important role. The possibility of similar correlations for complexes of triphosphates is also discussed. DA - 1988 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1988 T1 - Complexation of divalent copper, zinc and calcium ions by phosphate esters in aqueous solution TI - Complexation of divalent copper, zinc and calcium ions by phosphate esters in aqueous solution UR - http://hdl.handle.net/11427/17083 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/17083
dc.identifier.vancouvercitationKramer U. Complexation of divalent copper, zinc and calcium ions by phosphate esters in aqueous solution. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1988 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/17083en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.subject.otherEstersen_ZA
dc.subject.otherLigandsen_ZA
dc.subject.otherComplex compoundsen_ZA
dc.titleComplexation of divalent copper, zinc and calcium ions by phosphate esters in aqueous solutionen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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