Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens

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dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.advisorHorsnell, Williamen_ZA
dc.contributor.authorVira, Alykhanen_ZA
dc.date.accessioned2015-09-15T10:22:58Z
dc.date.available2015-09-15T10:22:58Z
dc.date.issued2013en_ZA
dc.description.abstractDuring the last decade, cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 subtype on macrophages has potent anti-inflammatory effects. However, the role for muscarinic receptor has not yet been conclusively characterized. In this study, we demonstrate that M3 muscarinic receptor subtype is required for optimal protective immunity to two pathogens; the nematode Nippostrongylus brasiliensis and the bacterium Salmonella enterica sp. Tyhpimurium. M3R deficient mice (M3R-/-) were susceptible to infection with N.brasiliensis with decreased production of the protective cytokine IL-13. Furthermore, stimulation of lymphocytes with muscarinic agonists enhanced TH2 cytokine production in an M3R dependent manner.en_ZA
dc.identifier.apacitationVira, A. (2013). <i>Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences. Retrieved from http://hdl.handle.net/11427/13966en_ZA
dc.identifier.chicagocitationVira, Alykhan. <i>"Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2013. http://hdl.handle.net/11427/13966en_ZA
dc.identifier.citationVira, A. 2013. Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Vira, Alykhan AB - During the last decade, cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 subtype on macrophages has potent anti-inflammatory effects. However, the role for muscarinic receptor has not yet been conclusively characterized. In this study, we demonstrate that M3 muscarinic receptor subtype is required for optimal protective immunity to two pathogens; the nematode Nippostrongylus brasiliensis and the bacterium Salmonella enterica sp. Tyhpimurium. M3R deficient mice (M3R-/-) were susceptible to infection with N.brasiliensis with decreased production of the protective cytokine IL-13. Furthermore, stimulation of lymphocytes with muscarinic agonists enhanced TH2 cytokine production in an M3R dependent manner. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens TI - Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens UR - http://hdl.handle.net/11427/13966 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13966
dc.identifier.vancouvercitationVira A. Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13966en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleRole of M3 muscarinic receptor in regulation of immunity to infectious pathogensen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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