Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis

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dc.contributor.advisorWilkinson, Robert Jen_ZA
dc.contributor.advisorWilkinson, Katalinen_ZA
dc.contributor.authorGideon, Hannah Priyadarshinien_ZA
dc.date.accessioned2014-12-30T06:34:33Z
dc.date.available2014-12-30T06:34:33Z
dc.date.issued2010en_ZA
dc.description.abstractStudies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As hypoxia is a relevant stimulus that MTB encounters in vivo, whole genome based transcriptional profiles of M. tuberculosis subject to prolonged hypoxia (described as the Enduring hypoxic response (EHR) were analyzed, to guide the discovery of novel potential anitgens, by a combined bioinformatic and empirical approach and to determine evidence of infection stage specific recognition.en_ZA
dc.identifier.apacitationGideon, H. P. (2010). <i>Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology. Retrieved from http://hdl.handle.net/11427/10500en_ZA
dc.identifier.chicagocitationGideon, Hannah Priyadarshini. <i>"Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2010. http://hdl.handle.net/11427/10500en_ZA
dc.identifier.citationGideon, H. 2010. Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Gideon, Hannah Priyadarshini AB - Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As hypoxia is a relevant stimulus that MTB encounters in vivo, whole genome based transcriptional profiles of M. tuberculosis subject to prolonged hypoxia (described as the Enduring hypoxic response (EHR) were analyzed, to guide the discovery of novel potential anitgens, by a combined bioinformatic and empirical approach and to determine evidence of infection stage specific recognition. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis TI - Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis UR - http://hdl.handle.net/11427/10500 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10500
dc.identifier.vancouvercitationGideon HP. Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10500en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Microbiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Microbiologyen_ZA
dc.titleStudies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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