South African marine compounds as anticancer agents

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dc.contributor.advisorHendricks, Denver Ten_ZA
dc.contributor.advisorDavies-Coleman, Michael Ten_ZA
dc.contributor.authorWhibley, Catherine Evelynen_ZA
dc.date.accessioned2014-10-11T12:17:01Z
dc.date.available2014-10-11T12:17:01Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references (leaves 149-163).en_ZA
dc.description.abstractOesophageal cancer is the most common cause of cancer related deaths among black males in South Africa. Currently there are very limited treatment options, and patients have a very poor prognosis, due in part to the late stage at which this cancer is usually detected. In this thesis we describe the establishment of a screening assay using an oesophageal cancer cell line as a model. It was our hope that this screen would allow us to identify compounds which have activity against oesophageal cancer, that could be used as lead agents for further development of chemotherapeutic agents. Once our screen was established, we tested a wide range of extracts from southern African marine organisms, supplied by our collaborators from Rhodes University, South Africa. The marine environment represents a rich, untapped repository of novel and interesting compounds, and through our collaboration we had access to a wide range of marine-derived extracts and compounds. During the course of this project we provided screening data to assist in activity-directed fractionation from five active marine extracts, giving rise to 15 compounds of varying activity. These included several groups of novel active compounds such as the makaluvic acids from the sponge Strongylodesma aliwaliensis and the malonganenones from the octocoral Leptogorgia gi/christii. The identification of a number of novel, active compounds through our screening program highlights the potential of marine organisms from the southern African coast as a source of novel drug leads.en_ZA
dc.identifier.apacitationWhibley, C. E. (2006). <i>South African marine compounds as anticancer agents</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/8393en_ZA
dc.identifier.chicagocitationWhibley, Catherine Evelyn. <i>"South African marine compounds as anticancer agents."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2006. http://hdl.handle.net/11427/8393en_ZA
dc.identifier.citationWhibley, C. 2006. South African marine compounds as anticancer agents. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Whibley, Catherine Evelyn AB - Oesophageal cancer is the most common cause of cancer related deaths among black males in South Africa. Currently there are very limited treatment options, and patients have a very poor prognosis, due in part to the late stage at which this cancer is usually detected. In this thesis we describe the establishment of a screening assay using an oesophageal cancer cell line as a model. It was our hope that this screen would allow us to identify compounds which have activity against oesophageal cancer, that could be used as lead agents for further development of chemotherapeutic agents. Once our screen was established, we tested a wide range of extracts from southern African marine organisms, supplied by our collaborators from Rhodes University, South Africa. The marine environment represents a rich, untapped repository of novel and interesting compounds, and through our collaboration we had access to a wide range of marine-derived extracts and compounds. During the course of this project we provided screening data to assist in activity-directed fractionation from five active marine extracts, giving rise to 15 compounds of varying activity. These included several groups of novel active compounds such as the makaluvic acids from the sponge Strongylodesma aliwaliensis and the malonganenones from the octocoral Leptogorgia gi/christii. The identification of a number of novel, active compounds through our screening program highlights the potential of marine organisms from the southern African coast as a source of novel drug leads. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - South African marine compounds as anticancer agents TI - South African marine compounds as anticancer agents UR - http://hdl.handle.net/11427/8393 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/8393
dc.identifier.vancouvercitationWhibley CE. South African marine compounds as anticancer agents. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/8393en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleSouth African marine compounds as anticancer agentsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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