Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies

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dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.authorMyburgh, Elmarieen_ZA
dc.date.accessioned2014-07-28T14:54:04Z
dc.date.available2014-07-28T14:54:04Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references (leaves 114-142).
dc.description.abstractLymphocyte-specific reconstitution of IL-4Ra was recently established by intercrossing lymphocyte-specific human IL-R4a transgenic mice with mIL-4Ra-deficient mice. Human IL-4Ra may bind to mouse yc resulting in a chimeric receptor specific for human IL-4 but not mouse IL-4. This provides us with and inducible IL-4 system. The aim of this study was to investigate in vitro and in vivo characteristics of our novel hlL-4Ra Tg/mIL-4Ra+/- mouse model.en_ZA
dc.identifier.apacitationMyburgh, E. (2006). <i>Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/3114en_ZA
dc.identifier.chicagocitationMyburgh, Elmarie. <i>"Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2006. http://hdl.handle.net/11427/3114en_ZA
dc.identifier.citationMyburgh, E. 2006. Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Myburgh, Elmarie AB - Lymphocyte-specific reconstitution of IL-4Ra was recently established by intercrossing lymphocyte-specific human IL-R4a transgenic mice with mIL-4Ra-deficient mice. Human IL-4Ra may bind to mouse yc resulting in a chimeric receptor specific for human IL-4 but not mouse IL-4. This provides us with and inducible IL-4 system. The aim of this study was to investigate in vitro and in vivo characteristics of our novel hlL-4Ra Tg/mIL-4Ra+/- mouse model. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies TI - Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies UR - http://hdl.handle.net/11427/3114 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3114
dc.identifier.vancouvercitationMyburgh E. Lymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studies. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3114en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleLymphocyte-specific reconstitution of IL-4Ra-deficient mice : characterization and infectious disease studiesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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