Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers

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dc.contributor.advisorNtusi, Ntobeko
dc.contributor.advisorSkatulla, Sebastian
dc.contributor.authorAremu, Olukayode Olasunkanmi
dc.date.accessioned2023-09-08T10:31:11Z
dc.date.available2023-09-08T10:31:11Z
dc.date.issued2023
dc.date.updated2023-09-08T10:11:50Z
dc.description.abstractBackground: Rheumatic heart disease (RHD), concomitant to valvular damage, heart failure, arrhythmias and pulmonary hypertension is the major source of cardiovascular morbidity and mortality in the young, predominantly in low- and middle-income countries (LMICs). We investigated the association of valve lesions in RHD with cardiovascular magnetic resonance (CMR) tissue characteristics and autophagy markers, in this study. Methods: Forty-seven (47) patients (42 ± 12.8 years), with advanced RHD, awaiting valve replacement, confirmed on echocardiography, and matched with 30 healthy controls (39 ± 12.1 years), were scanned using a 3T Siemens Magnetom Skyra. CMR parameters were derived from the following acquisitions: cine imaging of the short and long axes, T1 mapping (MOLLI, 5(3)3, estimation of ECV and late gadolinium enhancement (LGE) imaging. For the cellular study, we analysed the immunoexpression of Beclin, LC3, p62, BAX, Bcl-2 and caspase-3 in patients confirmed with RHD and valvular heart disease
dc.identifier.apacitationAremu, O. O. (2023). <i>Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers</i>. (). ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/38460en_ZA
dc.identifier.chicagocitationAremu, Olukayode Olasunkanmi. <i>"Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers."</i> ., ,Faculty of Health Sciences ,Department of Medicine, 2023. http://hdl.handle.net/11427/38460en_ZA
dc.identifier.citationAremu, O.O. 2023. Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers. . ,Faculty of Health Sciences ,Department of Medicine. http://hdl.handle.net/11427/38460en_ZA
dc.identifier.ris TY - Doctoral Thesis AU - Aremu, Olukayode Olasunkanmi AB - Background: Rheumatic heart disease (RHD), concomitant to valvular damage, heart failure, arrhythmias and pulmonary hypertension is the major source of cardiovascular morbidity and mortality in the young, predominantly in low- and middle-income countries (LMICs). We investigated the association of valve lesions in RHD with cardiovascular magnetic resonance (CMR) tissue characteristics and autophagy markers, in this study. Methods: Forty-seven (47) patients (42 ± 12.8 years), with advanced RHD, awaiting valve replacement, confirmed on echocardiography, and matched with 30 healthy controls (39 ± 12.1 years), were scanned using a 3T Siemens Magnetom Skyra. CMR parameters were derived from the following acquisitions: cine imaging of the short and long axes, T1 mapping (MOLLI, 5(3)3, estimation of ECV and late gadolinium enhancement (LGE) imaging. For the cellular study, we analysed the immunoexpression of Beclin, LC3, p62, BAX, Bcl-2 and caspase-3 in patients confirmed with RHD and valvular heart disease DA - 2023_ DB - OpenUCT DP - University of Cape Town KW - cardiovascular magnetic resonance KW - autophagy LK - https://open.uct.ac.za PY - 2023 T1 - Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers TI - Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers UR - http://hdl.handle.net/11427/38460 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/38460
dc.identifier.vancouvercitationAremu OO. Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers. []. ,Faculty of Health Sciences ,Department of Medicine, 2023 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/38460en_ZA
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.subjectcardiovascular magnetic resonance
dc.subjectautophagy
dc.titleCharacterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationlevelPhD
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