Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents

dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorMusonda, Chitalu Christopheren_ZA
dc.date.accessioned2015-01-08T20:06:56Z
dc.date.available2015-01-08T20:06:56Z
dc.date.issued2005en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe work in this thesis is threefold: (i) A new series of antiplasmodial agents were initially designed based on the β-amino alcohol bioactiphore, a subunit that is found in a number of antimalarial agents. (ii) Various thiosemicarbozones and semicarbozones were designed and synthesized as potential mechanism-based inhibiotrs of parasitic cysteine proteases. (iii) Multicomponenet reactions offer the advantage of introducing chemical diversity in fewer steps than conventional multi step organic synthesis. New chloroquine-type compounds were designed and synthesized using the Ugi 4 component condensation reaction and its variants. The synthesized compounds ranged from simple peptidic molecules to rigid heterocycles.en_ZA
dc.identifier.apacitationMusonda, C. C. (2005). <i>Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/11811en_ZA
dc.identifier.chicagocitationMusonda, Chitalu Christopher. <i>"Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2005. http://hdl.handle.net/11427/11811en_ZA
dc.identifier.citationMusonda, C. 2005. Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Musonda, Chitalu Christopher AB - The work in this thesis is threefold: (i) A new series of antiplasmodial agents were initially designed based on the &#946;-amino alcohol bioactiphore, a subunit that is found in a number of antimalarial agents. (ii) Various thiosemicarbozones and semicarbozones were designed and synthesized as potential mechanism-based inhibiotrs of parasitic cysteine proteases. (iii) Multicomponenet reactions offer the advantage of introducing chemical diversity in fewer steps than conventional multi step organic synthesis. New chloroquine-type compounds were designed and synthesized using the Ugi 4 component condensation reaction and its variants. The synthesized compounds ranged from simple peptidic molecules to rigid heterocycles. DA - 2005 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents TI - Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents UR - http://hdl.handle.net/11427/11811 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11811
dc.identifier.vancouvercitationMusonda CC. Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2005 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11811en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleAntimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agentsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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