Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia

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dc.contributor.advisorKotwal, Girish Jen_ZA
dc.contributor.advisorKahn, Delen_ZA
dc.contributor.authorGhebremariam, Yohannes Ten_ZA
dc.date.accessioned2014-07-28T08:19:13Z
dc.date.available2014-07-28T08:19:13Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references (leaves 133-147)
dc.description.abstractIn transplantation, vascularized organs often suffer the consequences of ischemic damage as well as reperfusion injury following the reestablishment of blood flow. The induced ischemialreperfusion (I/R) damage is usually associated with the accumulation of injurious complement components. The vaccinia virus complement control protein (VCP) has the ability to simultaneously inhibit the classical and the alternative complement pathways by binding to the early components C3b and C4b. The complement component C3 is known to be the central route to all of the known complement activation pathways. As a result, it is involved in a number of complement-mediated ailments including renal ischemia/reperfusion injury. The objectives of this study were to initially evaluate the in vitro roles of the natural VCP and the humanized recombinant VCP (hrVCP), and then to establish their in vivo roles in a renal I/R injury model.en_ZA
dc.identifier.apacitationGhebremariam, Y. T. (2006). <i>Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Virology. Retrieved from http://hdl.handle.net/11427/2726en_ZA
dc.identifier.chicagocitationGhebremariam, Yohannes T. <i>"Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2006. http://hdl.handle.net/11427/2726en_ZA
dc.identifier.citationGhebremariam, Y. 2006. Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Ghebremariam, Yohannes T AB - In transplantation, vascularized organs often suffer the consequences of ischemic damage as well as reperfusion injury following the reestablishment of blood flow. The induced ischemialreperfusion (I/R) damage is usually associated with the accumulation of injurious complement components. The vaccinia virus complement control protein (VCP) has the ability to simultaneously inhibit the classical and the alternative complement pathways by binding to the early components C3b and C4b. The complement component C3 is known to be the central route to all of the known complement activation pathways. As a result, it is involved in a number of complement-mediated ailments including renal ischemia/reperfusion injury. The objectives of this study were to initially evaluate the in vitro roles of the natural VCP and the humanized recombinant VCP (hrVCP), and then to establish their in vivo roles in a renal I/R injury model. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia TI - Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia UR - http://hdl.handle.net/11427/2726 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/2726
dc.identifier.vancouvercitationGhebremariam YT. Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Virology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/2726en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Virologyen_ZA
dc.titleEvaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemiaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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