Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers
| dc.contributor.advisor | Barnes, Karen | |
| dc.contributor.author | Kagoro, Frank | |
| dc.date.accessioned | 2025-09-01T07:13:05Z | |
| dc.date.available | 2025-09-01T07:13:05Z | |
| dc.date.issued | 2025 | |
| dc.date.updated | 2025-09-01T07:09:27Z | |
| dc.description.abstract | The spread of antimalarial drug resistance threatens global, regional and national malaria elimination efforts. Despite being preventable and treatable, malaria still claims over half a million lives globally, with over 95% of malaria cases and deaths occurring in Africa. Antimalarial drug resistance threatens progress in malaria control and elimination, especially in less-resourced health systems in developing countries. Malaria control and elimination efforts are facing stagnation of funding and competing resources with other potential pandemic pathogens like COVID-19, HIV, tuberculosis and non-communicable diseases. Regrettably, the malaria programmes and policymakers who are at the forefront of confronting antimalarial drug resistance often lack timely monitoring tools for evidence-based decision-making. This thesis used an iterative, sequential, explanatory, mixed-methods design to strengthen evidence on Plasmodium falciparum antimalarial drug resistance in Asia and South Africa. Through four thesis chapters of peer-reviewed manuscripts, the thesis presents innovative approaches to developing impactful policymaker-friendly tools for detection, reporting and responding to antimalarial drug resistance. Through co-design techniques, the thesis addresses major data challenges and developed guidelines and tools to support near-real-time antimalarial resistance monitoring. The thesis also highlights important processes and pinch points in rolling out an early warning system for antimalarial drug resistance in a pre- elimination setting in South Africa. This research contributes to best practices in summarising evidence for antimalarial drug resistance for policymakers and decision-makers. Furthermore, this thesis provides insights on the process of establishing an early warning system in a pre-elimination malaria setting, a context reflective of where several Southern African countries and Island states are heading in this decade. | |
| dc.identifier.apacitation | Kagoro, F. (2025). <i>Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/41654 | en_ZA |
| dc.identifier.chicagocitation | Kagoro, Frank. <i>"Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2025. http://hdl.handle.net/11427/41654 | en_ZA |
| dc.identifier.citation | Kagoro, F. 2025. Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers. . University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. http://hdl.handle.net/11427/41654 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Kagoro, Frank AB - The spread of antimalarial drug resistance threatens global, regional and national malaria elimination efforts. Despite being preventable and treatable, malaria still claims over half a million lives globally, with over 95% of malaria cases and deaths occurring in Africa. Antimalarial drug resistance threatens progress in malaria control and elimination, especially in less-resourced health systems in developing countries. Malaria control and elimination efforts are facing stagnation of funding and competing resources with other potential pandemic pathogens like COVID-19, HIV, tuberculosis and non-communicable diseases. Regrettably, the malaria programmes and policymakers who are at the forefront of confronting antimalarial drug resistance often lack timely monitoring tools for evidence-based decision-making. This thesis used an iterative, sequential, explanatory, mixed-methods design to strengthen evidence on Plasmodium falciparum antimalarial drug resistance in Asia and South Africa. Through four thesis chapters of peer-reviewed manuscripts, the thesis presents innovative approaches to developing impactful policymaker-friendly tools for detection, reporting and responding to antimalarial drug resistance. Through co-design techniques, the thesis addresses major data challenges and developed guidelines and tools to support near-real-time antimalarial resistance monitoring. The thesis also highlights important processes and pinch points in rolling out an early warning system for antimalarial drug resistance in a pre- elimination setting in South Africa. This research contributes to best practices in summarising evidence for antimalarial drug resistance for policymakers and decision-makers. Furthermore, this thesis provides insights on the process of establishing an early warning system in a pre-elimination malaria setting, a context reflective of where several Southern African countries and Island states are heading in this decade. DA - 2025 DB - OpenUCT DP - University of Cape Town KW - Antimalarial Drug KW - Malaria KW - Policymakers LK - https://open.uct.ac.za PB - University of Cape Town PY - 2025 T1 - Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers TI - Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers UR - http://hdl.handle.net/11427/41654 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/41654 | |
| dc.identifier.vancouvercitation | Kagoro F. Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers. []. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/41654 | en_ZA |
| dc.language.iso | en | |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Medicine | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.publisher.institution | University of Cape Town | |
| dc.subject | Antimalarial Drug | |
| dc.subject | Malaria | |
| dc.subject | Policymakers | |
| dc.title | Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers | |
| dc.type | Thesis / Dissertation | |
| dc.type.qualificationlevel | Doctoral | |
| dc.type.qualificationlevel | PhD |