Extracellular matrix gene sequence variant analyses and Achilles tendinopathy

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dc.contributor.advisorSeptember, Alisonen_ZA
dc.contributor.advisorSchwellnus, Martinen_ZA
dc.contributor.advisorCollins, Malcolmen_ZA
dc.contributor.authorSaunders, Colleen Jayneen_ZA
dc.date.accessioned2014-07-28T18:14:28Z
dc.date.available2014-07-28T18:14:28Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references)
dc.description.abstractThe primary aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this genetic risk. Candidate genes (COMP, THBS2, COL27A1, TNC, COL3A1, COL5A2 and COL5A3) were selected based on their chromosomal location and/or the biological function of their encoded proteins within the extracellular matrix (ECM) of the tendon.en_ZA
dc.identifier.apacitationSaunders, C. J. (2013). <i>Extracellular matrix gene sequence variant analyses and Achilles tendinopathy</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3199en_ZA
dc.identifier.chicagocitationSaunders, Colleen Jayne. <i>"Extracellular matrix gene sequence variant analyses and Achilles tendinopathy."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2013. http://hdl.handle.net/11427/3199en_ZA
dc.identifier.citationSaunders, C. 2013. Extracellular matrix gene sequence variant analyses and Achilles tendinopathy. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Saunders, Colleen Jayne AB - The primary aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this genetic risk. Candidate genes (COMP, THBS2, COL27A1, TNC, COL3A1, COL5A2 and COL5A3) were selected based on their chromosomal location and/or the biological function of their encoded proteins within the extracellular matrix (ECM) of the tendon. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Extracellular matrix gene sequence variant analyses and Achilles tendinopathy TI - Extracellular matrix gene sequence variant analyses and Achilles tendinopathy UR - http://hdl.handle.net/11427/3199 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3199
dc.identifier.vancouvercitationSaunders CJ. Extracellular matrix gene sequence variant analyses and Achilles tendinopathy. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3199en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherHuman Biologyen_ZA
dc.titleExtracellular matrix gene sequence variant analyses and Achilles tendinopathyen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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