Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha

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dc.contributor.advisorLopata, Andreasen_ZA
dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.authorNieuwenhuizen, Natalieen_ZA
dc.date.accessioned2014-07-28T14:54:06Z
dc.date.available2014-07-28T14:54:06Z
dc.date.issued2007en_ZA
dc.descriptionIncludes bibliographical references (p. 117-127).
dc.description.abstractThe fish-parasitizing nematode Anisakis pegreffii induces gastrointestinal disease and allergy when ingested by humans, and can cause occupational allergy in seafood processing workers. The present study examines immune and allergic responses to A. pegreffii in wildtype and gene deficient mice, with special focus on interleukin(IL)-4, IL-13, and the IL-4 receptor alpha (IL-4Rα). Experimental murine models of Anisakis infection, Anisakis-induced anaphylaxis and Anisakis-induced dermatitis were established in order to gain insight into the immune responses generated against Anisakis and unravel mechanisms of allergic disease.en_ZA
dc.identifier.apacitationNieuwenhuizen, N. (2007). <i>Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/3115en_ZA
dc.identifier.chicagocitationNieuwenhuizen, Natalie. <i>"Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2007. http://hdl.handle.net/11427/3115en_ZA
dc.identifier.citationNieuwenhuizen, N. 2007. Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Nieuwenhuizen, Natalie AB - The fish-parasitizing nematode Anisakis pegreffii induces gastrointestinal disease and allergy when ingested by humans, and can cause occupational allergy in seafood processing workers. The present study examines immune and allergic responses to A. pegreffii in wildtype and gene deficient mice, with special focus on interleukin(IL)-4, IL-13, and the IL-4 receptor alpha (IL-4Rα). Experimental murine models of Anisakis infection, Anisakis-induced anaphylaxis and Anisakis-induced dermatitis were established in order to gain insight into the immune responses generated against Anisakis and unravel mechanisms of allergic disease. DA - 2007 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha TI - Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha UR - http://hdl.handle.net/11427/3115 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3115
dc.identifier.vancouvercitationNieuwenhuizen N. Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2007 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3115en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleImmune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alphaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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