The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population

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dc.contributor.advisorNicol, Marken_ZA
dc.contributor.advisorWilkinson, R Jen_ZA
dc.contributor.authorSarkar, Rajeshen_ZA
dc.date.accessioned2014-07-28T08:17:43Z
dc.date.available2014-07-28T08:17:43Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractThe genome structure of Mycobacterium tuberculosis is strongly clonal, in the absence of horizontal gene transfer. Thus it is feasible that clonal lineages may exhibit particular phenotypic characteristics, which may, in turn, result in differences in virulence or influence their association with particular host populations. Indeed, the global distribution of M. tuberculosis strains is not uniform and certain strain lineages predominate in particular geographical areas. Further, there is evidence that some strain lineages are emerging, suggesting differences in virulence. Firstly, we investigated the association between strain genotype of M. tuberculosis and in vitro correlates of virulence such as growth phenotype and cytokine induction in the monocyte-derived macrophage (MDM) model.en_ZA
dc.identifier.apacitationSarkar, R. (2013). <i>The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology. Retrieved from http://hdl.handle.net/11427/2719en_ZA
dc.identifier.chicagocitationSarkar, Rajesh. <i>"The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2013. http://hdl.handle.net/11427/2719en_ZA
dc.identifier.citationSarkar, R. 2013. The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Sarkar, Rajesh AB - The genome structure of Mycobacterium tuberculosis is strongly clonal, in the absence of horizontal gene transfer. Thus it is feasible that clonal lineages may exhibit particular phenotypic characteristics, which may, in turn, result in differences in virulence or influence their association with particular host populations. Indeed, the global distribution of M. tuberculosis strains is not uniform and certain strain lineages predominate in particular geographical areas. Further, there is evidence that some strain lineages are emerging, suggesting differences in virulence. Firstly, we investigated the association between strain genotype of M. tuberculosis and in vitro correlates of virulence such as growth phenotype and cytokine induction in the monocyte-derived macrophage (MDM) model. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population TI - The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population UR - http://hdl.handle.net/11427/2719 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/2719
dc.identifier.vancouvercitationSarkar R. The innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host population. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/2719en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Microbiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Microbiologyen_ZA
dc.titleThe innate immune response to Mycobacterium tuberculosis is dependent on strain lineage and on host populationen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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