The therapeutic importance of isoniazid metabolism in elderly patients

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dc.contributor.advisorFolb, Peter Ien_ZA
dc.contributor.authorWalubo, Andrewen_ZA
dc.date.accessioned2018-01-29T07:14:35Z
dc.date.available2018-01-29T07:14:35Z
dc.date.issued1995en_ZA
dc.description.abstractThis is a study of the role of oxygen free radicals in isoniazid induced toxicity and its implications on the safety of isoniazid containing regimens in elderly patients. During isoniazid metabolism, toxic metabolites are produced which, together with isoniazid, may lead to toxicity by mechanism (s) yet unknown. Understanding the mechanism of toxicity is important for effective management and prevention of isoniazid induced toxicity. Elderly patients take priority for this consideration because isoniazid is more toxic in these people. Consequently, "the therapeutic importance of isoniazid metabolism in elderly patients" was found a suitable title for this work. lsoniazid metabolites; acetylisoniazid, monoacetyl-hydrazine and diacetylhydrazine were synthesized and characterized by thin layer chromatography, high performance liquid chromatography (HPLC), ultra-violet absorption spectra and mass spectrometry. Thereafter, these compounds together with hydrazine were used in the subsequent experiments.en_ZA
dc.identifier.apacitationWalubo, A. (1995). <i>The therapeutic importance of isoniazid metabolism in elderly patients</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/27052en_ZA
dc.identifier.chicagocitationWalubo, Andrew. <i>"The therapeutic importance of isoniazid metabolism in elderly patients."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 1995. http://hdl.handle.net/11427/27052en_ZA
dc.identifier.citationWalubo, A. 1995. The therapeutic importance of isoniazid metabolism in elderly patients. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Walubo, Andrew AB - This is a study of the role of oxygen free radicals in isoniazid induced toxicity and its implications on the safety of isoniazid containing regimens in elderly patients. During isoniazid metabolism, toxic metabolites are produced which, together with isoniazid, may lead to toxicity by mechanism (s) yet unknown. Understanding the mechanism of toxicity is important for effective management and prevention of isoniazid induced toxicity. Elderly patients take priority for this consideration because isoniazid is more toxic in these people. Consequently, "the therapeutic importance of isoniazid metabolism in elderly patients" was found a suitable title for this work. lsoniazid metabolites; acetylisoniazid, monoacetyl-hydrazine and diacetylhydrazine were synthesized and characterized by thin layer chromatography, high performance liquid chromatography (HPLC), ultra-violet absorption spectra and mass spectrometry. Thereafter, these compounds together with hydrazine were used in the subsequent experiments. DA - 1995 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1995 T1 - The therapeutic importance of isoniazid metabolism in elderly patients TI - The therapeutic importance of isoniazid metabolism in elderly patients UR - http://hdl.handle.net/11427/27052 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27052
dc.identifier.vancouvercitationWalubo A. The therapeutic importance of isoniazid metabolism in elderly patients. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 1995 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27052en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherClinical Pharmacologyen_ZA
dc.titleThe therapeutic importance of isoniazid metabolism in elderly patientsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameMDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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